purpose： individual guidance have the influences on patients with chronic obstructive pulmonary disease using a mechanical ventilation for the first time。Method：93 patients with chronic obstructive pulmonary disease (COPD) patients were randomized into control group (46) and the observation group (47). The control group patients were treated in traditional routine; the observation group patients were implemented by individual guidance on the basis of conventional treatment. An evaluation was given among the two groups by different time without breathing machine

tolerance rate

arterial blood gas results

the mechanical ventilation rate and the number of total of patients in ICU.Result：Individualized instruction help to improve patient use breathing machine which promoter noninvasive mechanical ventilation.