Objective：To study the efficacy and safety of Levetiracetam（Lev） monotherapy for different types of infantile epilepsy. Methods：Self controlled follow-up study was conducted for 56 patients with different types of infantile epilepsy using Lev oral monotherapy. Dose of Lev was initially 10 mg/（kg·d）（being administered two times a day），increased by 5-10 mg/（kg·d） every 3-7 d，maintained at 20-40 mg/（kg·d） and finally was increased to 35 mg/kg within 1-2 week. Efficacy and adverse reaction were observed after the treatment. Results：Complete seizure control was found in 29 cases，accounting for 51.78%；effective in 15 cases，accounting for 26.78%；invalid in 12 cases，accounting for 21.44%. Adverse reactions were mainly anorexia，lethargy，emotional rage and behavioral abnormality. Conclusions：Lev monotherapy is effective and safe in the treatment of different types of infantile epilepsy，especially for complex partial seizures and myoclonic seizures. With few adverse reactions，it is a good antiepileptic drug for epilepsy in infants and worth popularizing.