Objective：To explore the correlation between clinical risk factors and prognosis in premature coronary heart disease （PCHD） after revascularization and to provide the scientific references for prevention，cure and prognosis of PCHD. Methods：Totally 2 134 patients who received percutaneous coronary intervention（PCI） or coronary artery bypass graft（CABG） from February 1st，2000 to January 31st，2010 in our hospital were selected. All the patients were divided into two groups by age and gender，namely premature group and control group. The differences in the general condition and blood biochemical inspection results between the two groups were analyzed. The clinical risk factors in patients with PCHD after revascularization were discussed. After operation，the premature group was followed-up with an average of 24 months. COX regression model was used to find the risk factors affecting the postoperative prognosis of PCI or CABG. Results：The smoking history，family history of CHD，level of total cholesterol（TC），triglyceride（TG），plasma fibrinogen（Fig） and hemoglobin（HGB） were the risk factors for PCHD. The smoking history，family history of CHD，high level of TC and the low level of HGB were the risk factors for postoperative prognosis of PCI or CABG. Conclusions：Patients with PCHD after the revascularization should take some targeted interventions to cope with the high risk factors of PCHD，strengthen the smoking control and rational diet propaganda and pay high attention to those with the positive family history of CHD.