Objectives：To research into the characteristics of changes of life quality and symptom at 4 months postoperatively in pa－tients with lung cancer and to analyze its influencing factors. Methods：The life quality of 113 patients with lung cancer at the 1st， 2nd and 4th months after surgery was assessed by using the Chinese version of European organization for research and treatment of cancer quality of life questionnaire-core 30（EORTC QLQ-C30） and EORTC QLQ-lung cancer 13（EORTC QLQ-LC13） scale and the data were analyzed by adopting descriptive statistics and multiple linear regression. Results：At the 4 th months，the function and overall life quality of patients were improved significantly except cognitive function（P<0.05）. Fatigue，dyspnoea，appetite loss，cough－ing，chest pain，pain in the arm or shoulder were alleviated significantly（P<0.05），however，stabling pain in the hands and feet was worsened（P<0.05），other symptoms has no significant changes. The influencing factors of life quality included depression，smoking history and adjuvant therapy. Conclusions：At the 4th month after the surgery，the overall life quality is improved and most symptoms are eased，however，fatigue and role function obstacle are still existed and should be attached importance to.