Objective：To approach the expressions and significances of estrogen receptor（ER），progesterone recetor（PR），human epi－dermal growth factor receptor-2（HER-2），Ki67，Nm23 and P53 in multicentric breast cancer. Methods：Clinical and pathological data of 45 cases of multicentric breast cancer from 2005 to 2010 in the affiliated tumor hospital of Xinjiang medical university were stud－ied retrospectively and 60 cases unilateral single breast cancer were selected as the control. Results：①The positive rates of HER-2 and Ki67 were higher in multicentric breast cancer than in unilateral single breast cancer，with significant differences（P＜0.05）. The positive rate of Nm23 was lower in multicentric breast cancer than in unilateral single breast cancer，with significant differences（P＜0.05）. The positive rates of ER，PR and P53 were lower in multicentric breast cancer than in unilateral single breast cancer，with significant differences（P ＞0.05）.②The differences in the expression of ER，PR，HER-2，Ki67，Nm23 and P53 between special and non special multicentric breast cancer were insignificant（P ＞0.05）. ③The expression of PR was lower in multicentric breast can－cer with high histological differentiation than in those with low histological differentiation，with significant differences（P ＜0.05）. The ER protein expression was lower in multicentric breast cancer with high histological differentiation than in those with low histological differentiation，with significant differences（P >0.05）. Conclusions：The detection of ER and PR can not only guide the clinical drug administration but also indicate the progression of breast cancer. HER-2，Ki67 and Nm23 may be related with multicentric breast cancer，which may be high-risk factors of multicentric breast cancer.