Objective：To observe the efficacy and value of applying autologous free skin graft in the treatment of refractory wound. Methods：Totally 352 patients with refractory wound were selected. Wound treatment，basic disease treatment and systemic support were performed until the granulation became fresh. Autologous free skin graft（the surface layer and middle thick layer） was provided according to parts of the wound. Pressure dress was followed soon by using burn dressing. Results：Among the 352 cases，322 under－went stageⅠdebridement and skin graft，30 underwent stageⅠdebridement and stageⅡskin graft. Among 340 cases of skin graft，90% flaps were survived postoperatively. Twelve cases had less than 1/3-1/2 flaps died，however，the wound was healed and the patients were discharged by dressing or replanting. Average hospital duration was （16 ± 2） d，and average postoperative recovery time was （19 ± 3） d. Conclusion：Autologous free skin graft can promote the recovery of refractory wound and improve the survival rate.