Objective：To discuss the risk of cerebral thrombosis after implantation of metal stent via cerebral vascular intervention. Methods：Clinical data of 87 patients who underwent implantation of metal stent via cerebral vascular intervention in our department during 2009-2010 were retrospectively summarized，and the postoperative conditions were followed for 2 years. Serum D-dimer level and platelet level were monitored. Risk factors of new cerebral infarction at acute，subacute and advanced stages were tested by single factor analysis and Logistic regression. Results：There were 11 cases（12.64%） with new cerebral infarction after metal stent implanta－tion，7 at acute and subacute stages while 4 at advanced stage. Not taking aspirin on schedule，renal dysfunction，history of heart stent disease，higher level of platelet aggregation were high risk factors of new cerebral infarction at acute and subacute stages（P<0.05 or P≈0.05），while hypertension，not taking aspirin on schedule，diabetes，hyperlipidemia were high risk factors of cerebral thrombosis for－mation at advanced stage（P<0.05）. Failure to take aspirin on schedule was the independent risk factor at all stages. Conclusions：Regular using of anti-platelet aggregation therapy may reduce the risk of ischemic stroke after metal stent implantation via cerebral vascular intervention.