Objective：To create Morphine addiction model by conditioned place preference firstly and then to create epilepsy model on the basis of Morphine addiction，finally to study whether Morphine addiction and epilepsy exert effects on spatial learning and memorizing of institute of cancer research（ICR） mice from behavioral by water maze. Methods：Totally 40 ICR mice having excellent performance by early platform of natural preference and training of water maze were selected. All these mice were equally divided into Morphine addiction complicated with epilepsy group

Morphine addiction group

epilepsy group and control group（n=10）. Seven days continuous injection of Morphine was used to create Morphine addiction model while Pilocarpine was injected to create epilepsy model. Water maze test was performed to observe the learning and memorizing of mice. Results：Water maze escape latency was longer in Morphine addiction complicated epilepsy mice than in epilepsy mice. Conclusion：Morphine addition and epilepsy exert synergistic effect on learning and memory of ICR mice.