Effect of Puerarin on the proliferation of choroidal vascular endothelial cells in vitro

WU Ningling; WU Yini; ZHUANG Zengyuan; XIA Yu

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Effect of Puerarin on the proliferation of choroidal vascular endothelial cells in vitro

更新时间：2023-12-18

- Effect of Puerarin on the proliferation of choroidal vascular endothelial cells in vitro
- Journal of Chongqing Medical University Vol. 37, Issue 11, Pages: 933-935(2012)
- 作者机构：
  
  中国中医科学院眼科医院眼科,北京,100040
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012，
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WU Ningling, WU Yini, ZHUANG Zengyuan, et al. Effect of Puerarin on the proliferation of choroidal vascular endothelial cells in vitro. [J]. Journal of Chongqing Medical University 37(11):933-935(2012)
DOI：

WU Ningling, WU Yini, ZHUANG Zengyuan, et al. Effect of Puerarin on the proliferation of choroidal vascular endothelial cells in vitro. [J]. Journal of Chongqing Medical University 37(11):933-935(2012) DOI：

摘要

目的：观察不同浓度葛根素（Puerarin，Pur）对体外培养脉络膜血管内皮细胞（Choroidal vascular endothelial cells， CVECs）增殖的影响。方法：取第3代人CVECs用于实验。实验组中加入含不同浓度的Pur培养液，细胞对照组加入等量空白培养液。24 h及48 h后采用四甲基偶氮唑蓝比色法检测血管内皮细胞的增殖情况。结果：与细胞对照组比较

0.05、0.50、5.00 μg/ml和50 μg/ml Pur组作用24 h及48 h后CVECs A值均增加（P<0.01）。结论：Pur对体外培养的CVECs有明显的促进增殖作用，其作用与Pur的剂量有关。

Abstract

Objective：To investigate the effect of different concentrations of Puerarin（Pur） on the proliferation of choroidal vascular endothelial cells（CVECs） in vitro. Methods：The third generation of CVECs were used for the research. The CVECs in experimental group were exposed to different concentrations of Pur while those in cell control group were exposed to equal amount of blank medi－um. The effect of Pur on the proliferation of cells was measured by methyl thiazolyl thiazolium（MTT） assay. Results：CVECs cultured with 0.05，0.50，5.00 μg/ml and 50.00 μg/ml Pur showed increase in absorbance（A） value at 24 h and 48 h after treatment（P<0.01）. Conclusion：Pur can obvious promote the proliferation of CVECs，which is related with the dosage of Pur.

关键词

葛根素脉络膜血管内皮细胞增殖

Keywords

Puerarinchoroidal vascular endothelial cellsproliferation

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