Objectve：To investigate the expressions of osteopontin（OPN） and CD68 in IgA nephropathy and their relationship with re－nal interstitial injury. Methods：According to biopsy results，renal biopsy specimens from 26 patients with diagnosed primary IgA nephropathy were selected as experimental group. According to Lee’s method，pathological injuries were divided intoⅠ-Ⅴ grades and renal interstitial injuries were divided into 0-3 levels. The other four normal renal tissue specimens taken from patients with renal trauma or renal tumor were taken as control group. Blood pressure，serum creatinine，creatinine clearance rate were collected and cal－culated. Expressions of OPN and CD68 in renal tissues were investigated by immunohistochemistry. mRNA expressions of OPN were investigated by RT-PCR. Results：（1）Up to 86% patients with IgA nephropathy had renal interstitial injury. Expressions of CD68 in experiment group were significantly higher than those in control group，with statistical differences. （2）Expressions of OPN and mRNA were higher in experiment group than in control group（P＜0.05） and were not correlated with renal interstitial injuries. Expressions of CD68 in renal interstitial substance were positively correlated with renal interstitial injuries. Expressions of OPN were positively cor－related with expressions of CD68 in renal interstitial substance（rs=0.545，P=0.044）. Conclusions：Monocyte/macrophage infiltration in IgA nephropathy is involved in renal interstitial injury. OPN，associated with inflammation，participates in renal interstitial injury by mediating mononuclear and macrophages.