Objective：To analyze the disease constitution and death cause of hospitalized patients with cardiovascular diseases and to offer some epidemiology evidences for clinic and research of cardiology. Methods：Patients discharged from the cardiology department of the First Affiliated Hospital of Chongqing Medical University from January 2011 to December 2012 were retrospectively investigated and were divided into 4 groups：aged below 44，aged 45 to 59，aged 60 to 74 and aged over 75. Their disease constitution，death cause and proportion of heart failure and sudden cardiac death were analyzed. Results：There were 5 096 male and 5 212 female patients and the average age was （65.16±14.37） years. The top three diseases leading to hospitalization were coronary heart disease（CHD），hy－pertension and arrhythmia with constituent ratios of 41.29%，27.19% and 10.41% respectively. The top three diseases leading to hos－pitalization were similar between males and females，but different among different age groups：in 12-44 age group，the top three dis－eases were arrhythmia，hypertension and vital myocarditis；the top three diseases were the same between 45-49 age group and 60-74 age group；in 75-105 age group；the top three diseases were CHD，hypertension and sick sinus syndrome. There were 117 deceased among 10 308 inpatients and the mortality was 1.14%. The top three death cause diseases were CHD（71 cases，60.68%），hyperten－sion（17 cases，14.53%），rheumatic heart disease（15 cases，12.85%）. The direct death causes diseases were heart failure（62 cases，52.99%） and sudden cardiac death（33 cases，28.21%）. Conclusions：CHD and hypertension are the leading causes of hospitalization and death of patients with cardiovascular diseases，which should be better prevented and controlled.