Expressions of KAI1/CD82 in colorectal carcinoma and their relationship with clinicopathological characteristics

JI Runyuan; SHI Enyi; WANG Yongshi; LI Xiaoning; ZHAO Yufang; FENG Zhenqing

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Expressions of KAI1/CD82 in colorectal carcinoma and their relationship with clinicopathological characteristics

更新时间：2023-12-18

- Expressions of KAI1/CD82 in colorectal carcinoma and their relationship with clinicopathological characteristics
- Journal of Chongqing Medical University Vol. 36, Issue 1, Pages: 33-36(2013)
- 作者机构：
  
  1. 江苏省淮阴卫生高等职业技术学校淮安市消化道肿瘤重点实验室,淮安,223300
  2. 江苏省苏州卫生职业技术学院病理教研室,苏州,215009
  3. 江苏省淮安市肿瘤医院病理科,淮安,223200
  4. 南京医科大学基础医学院病理学系,南京,210029
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013，
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JI Runyuan, SHI Enyi, WANG Yongshi, et al. Expressions of KAI1/CD82 in colorectal carcinoma and their relationship with clinicopathological characteristics. [J]. Journal of Chongqing Medical University 36(1):33-36(2013)
DOI：

JI Runyuan, SHI Enyi, WANG Yongshi, et al. Expressions of KAI1/CD82 in colorectal carcinoma and their relationship with clinicopathological characteristics. [J]. Journal of Chongqing Medical University 36(1):33-36(2013) DOI：

摘要

目的：探讨结直肠癌组织中KAI1/CD82的表达及其与肿瘤转移的关系。方法：应用组织芯片和免疫组织化学技术检测233例结直肠癌组织中KAI1/CD82的表达。结果：KAI1/CD82在结直肠癌组织中阳性率为51.5%，其表达与患者的性别、年龄、浸润深度、淋巴结转移无关，而与肿瘤的分化程度、Dukes分期有关（P<0.05）。二元Logistic回归前进法显示：分化是影响KAI1/CD82表达最显著因素[Exp（b）=0.431，P=0.038]。其次是Dukes分期[Exp（b）=0.363，P=0.043]。结直肠癌中KAI1/CD82在分化低的肿瘤和Dukes D期肿瘤表达降低。结论：KAI1/CD82在结直肠癌组织中的表达缺失与肿瘤的分化程度、分期密切相关，有望成为判断结直肠癌预后的新标志。

Abstract

Objective：To investigate expressions of KAI1/CD82 in colorectal carcinoma and their correlation with the metastasis of col－orectal carcinoma. Methods：Tissue microarray and immunohistochemistry were used to detect expressions of KAI1/CD82 in 233 cases of colorectal carcinoma. Results：Positive rate of KAI1/CD82 expression in colorectal carcinoma was 51.5%. Expressions of KAI1/CD82 were not correlated with patients’ sex，age，depth of infiltration and lymphnode metastasis，but were correlated with differentia－tion degrees and Dukes stages（P<0.05）. Forward stepwise binary Logistic regression revealed that differentiation was the most signifi－cant influencing factor of KAI1/CD82 expression，Exp（b）=0.431，P=0.038，followed by Dukes stage，Exp（b）=0.363，P=0.043. Expres－sions of KAI1/CD82 were decreased in colorectal carcinoma with poor differentiation and at Dukes D stage. Conclusions：Expressions of KAI1/CD82 are closely correlated with differentiation degrees and stages，which are expected to become a new target for tumor prognosis.

关键词

结直肠癌KAI1/CD82转移组织芯片免疫组织化学

Keywords

colorectal carcinomaKAI1/CD82metastasistissue microarrayimmunohistochemistry

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