A systematic review of neoadjuvant chemotherapy in the treatment of advanced nasopharyngeal carcinoma

YU Lin; SHEN Ai; LIU Rui; WEI Xufu; WU Zhongjun

您当前的位置：

首页 >

文章列表页 >

A systematic review of neoadjuvant chemotherapy in the treatment of advanced nasopharyngeal carcinoma

更新时间：2023-12-18

- A systematic review of neoadjuvant chemotherapy in the treatment of advanced nasopharyngeal carcinoma
- Journal of Chongqing Medical University Vol. 36, Issue 8, Pages: 929-935(2013)
- 作者机构：
  
  1. 重庆医科大学附属第一医院 1. 耳鼻咽喉科
  2. 普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013，
扫描看全文
YU Lin, SHEN Ai, LIU Rui, et al. A systematic review of neoadjuvant chemotherapy in the treatment of advanced nasopharyngeal carcinoma. [J]. Journal of Chongqing Medical University 36(8):929-935(2013)
DOI：

YU Lin, SHEN Ai, LIU Rui, et al. A systematic review of neoadjuvant chemotherapy in the treatment of advanced nasopharyngeal carcinoma. [J]. Journal of Chongqing Medical University 36(8):929-935(2013) DOI：

摘要

目的：新辅助化疗（neoadjuvant chemotherapy，NACT）被广泛应用于晚期鼻咽癌的治疗，但其疗效却受到争议。因此，本系统评价旨在评估NACT的有效性及安全性。方法：计算机检索Pubmed，Emabse，Cochrane Library数据库2013年4月1日之前的数据。只纳入以NACT为变量的随机对照试验。结果：7篇随机对照试验共1 463名患者进入本系统评价。Meta分析显示NACT能明显延长患者的无瘤生存期[风险比（hazard ratio，HR）：0.74，95%置信区间（confidence interval，CI）（0.64，0.86），P<0.001]及总生存期[HR：0.81，95%CI（0.68，0.96），P=0.013]，降低肿瘤局部复发率[相对风险比（relative risk，RR）：0.80，95%CI（0.67，0.97），P=0.022]及远处转移率[RR：0.70，95%CI（0.58，0.85），P<0.001]。但NACT不明显增加治疗相关的死亡率（P=0.806）。NACT过程中3～4级并发症发生率较高的是脱发（46.4%）、恶心/呕吐（20.1%）、中性粒细胞减少（35.9%），但NACT并不明显增加放疗或同期放化疗后的严重并发症发生率。结论：NACT对于晚期鼻咽癌患者是安全有效的。

Abstract

Objective：To evaluate the efficacy and safety of neoadjuvant chemotherapy（NACT） in the treatment of advanced nasopha－ryngeal carcinoma. Methods：Literature was searched online in Pubmed，Embase，Cochrane Library before April 1st，2013. Only ran－domized controlled trials（RCTs） with regard to NACT were included. Results：A total of 7 trials with 1 463 cases were included. Meta analyses demonstrated that NACT significantly improved the recurrence-free survival（HR：0.74，95%CI：0.64，0.86，P<0.001） and overall survival（HR：0.81，95%CI：0.68，0.96，P=0.013），decreased the locoregional recurrence（RR：0.80，95%CI：0.67，0.97，P=0.022） and the distant metastasis（RR：0.70，95%CI：0.58，0.85，P<0.001）. During NACT，the common grade 3-4 adverse events were hair loss（46.4%），nausea/vomiting（20.1%），neutropenia（35.9%）. However，NACT didn’t increased the treatment-related death（P=0.806） and grade 3-4 adverse events after treatments. Conclusions：NACT is an effective and safe modality for patients with advanced nasopharyngeal carcinoma.

关键词

新辅助化疗放疗鼻咽癌系统评价

Keywords

neoadjuvant chemotherapyradiotherapynasopharyngeal carcinomasystematic review

references

Views

586

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Radiotherapy combined with thermotherapy for treating patients with rectal cancer：a systematic review

Pathomics signature based on machine learning can predict the response to neoadjuvant chemotherapy in breast cancer patients

Postoperative electronic irradiation combined with brachytherapy by ¹⁹²Ir for keloid:an analysis of 105 patients

A systematic review of early oral refeeding versus conventional oral refeeding for acute pancreatitis

Effects of endometrial polyps and polypectomy on pregnancy rates of infertility patients:a systematic review

Related Author

Li Zheng

Mi Denghai

Cao Nong

Yang Kehu

Tian Jinhui

Ma Bin

Bai Zhenggang

Zhang Jieqiu

Related Institution

Department of Oncology，The Second People’s Hospital of Gansu Province

２. Evidence Based Medicine Center of Lanzhou University

Department of General Surgery，The First Clinical Medical College of Lanzhou University

Department of Medical Engineering Technology，School of Medical Information and Engineering，Southwest Medical University

Department of Pathology，The Affiliated Hospital of Southwest Medical University

⁰