Objective：To investigate therapeutic effects of repaglinide with insulin glargine and insulin pump in the treatment of type 2 diabetes mellitus. Methods：Totally 60 patients preliminary diagnosed as type 2 diabetes were randomly divided into two groups. Pa－tients in the two groups respectively accepted repaglinide with insulin glargine therapy and insulin pump therapy. Ｔhe dosage was ad－justed on the basis of blood glucose level. Changes in fasting blood glucose（FBG），2-hour postprandial plama glucose（2 h PG），rate of glycosylated hemoglobin A１c（HbA１c） and blood lipid of two groups before and after therapy were observed and compared. Results：Levels of FBG，2 h PG and rate of HbAlc were significantly degraded after the therapy（P=0.000 3，0.000 1，0.000 2；P=0.000 4，0.000 2，0.000 2；P＜0.05）. Levels of total triglyceride（TG），total cholesterol（TC） and low density lipoprotein-cholesterol（LDL-C） were decreased and levels of high density lipoprotein-cholesterol（HDL-C） were increased. There was no statistical difference in FBG，2 h PG，HbA1c，TC，TG，HDL-C and LDL-C between both groups（P=0.42，0.24，0.35，0.48，0.17，0.54，0.54，P ＞0.05）. Conclusions：Repaglin－ide with insulin glargine schedule is an ideally therapy for type 2 diabetes and its curative effect is equivalence to insulin pump.