Analysis on expressions of platelet activator combined-1 and P-selectin in serum of patients with acute cerebral infarction at different degrees

WANG Ling

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Analysis on expressions of platelet activator combined-1 and P-selectin in serum of patients with acute cerebral infarction at different degrees

更新时间：2023-12-18

- Analysis on expressions of platelet activator combined-1 and P-selectin in serum of patients with acute cerebral infarction at different degrees
- Journal of Chongqing Medical University Vol. 36, Issue 6, Pages: 638-640(2013)
- 作者机构：
  
  郑州人民医院急诊内科,郑州,450003
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- Published：2013，
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WANG Ling. Analysis on expressions of platelet activator combined-1 and P-selectin in serum of patients with acute cerebral infarction at different degrees. [J]. Journal of Chongqing Medical University 36(6):638-640(2013)
DOI：

WANG Ling. Analysis on expressions of platelet activator combined-1 and P-selectin in serum of patients with acute cerebral infarction at different degrees. [J]. Journal of Chongqing Medical University 36(6):638-640(2013) DOI：

摘要

目的：探讨不同病情程度急性脑梗死（acute cerebral infarction，ACI）患者血小板膜糖蛋白纤维蛋白原受体（platelet ac－tivator combined-1，PAC-1）和P选择素（也称CD62p）的表达情况。方法：分析我院自2008年10月至2011年10月收治的ACI患者287例，根据脑梗死病灶大小分为腔隙性脑梗死组76例、小面积脑梗死组125例和大面积脑梗死组86例，同时选取50例健康人群为对照组。采用流式细胞仪检测外周血PAC-1和CD62p含量。结果：ACI组PAC－1及CD62p水平（46.9 mg/L，28.4 ng/L）与对照组（29.6 mg/L，10.3 ng/L）比较均上升，差异有统计学意义（t=2.042，P=0.044；t=2.137，P=0.038）。腔隙性脑梗死组、小面积脑梗死和大面积脑梗死组在PAC－1及CD62p水平比较，差异有统计学意义（F=7.32，P=0.046；F=5.38，P=0.043）。小面积脑梗死组的PAC－1及CD62p水平（39.9 mg/L，24.5 ng/L）与腔隙脑梗死组（45.9 mg/L，29.1 ng/L）比较，差异有统计学意义（SNK-q＝4.417、4.129；P＝0.031、0.037）。大面积脑梗死组（53.9 mg/L，33.8 ng/L）与小面积脑梗死组、腔隙脑梗死组的PAC－1及CD62p水平比较，差异有统计学意义（SNK-q＝4.216、4.022；P=0.039、0.042）。结论：PAC-1 和CD62p 在ACI 患者中显著表达且可用于ACI病情严重程度的检测，临床检测对于预防和监控疾病发展具有重大意义。

Abstract

Objective：To explore expressions of platelet activator combined-1（PAC-1） and P-selectin（CD62p） in patients with acute cerebral infarction（ACI） at different degrees. Methods：Totally 287 patients with ACI from October 2008 to October 2011 were divid－ed into lacunar infarction group（n=76），small volume ACI group（n=125） and large volume ACI group（n=86）；50 health volunteer were served as control group. Levels of PAC-1 and CD62p were detected by flow cytometry. Results：Levels of PAC-1 and CD62p were increased in ACI group（46.9 mg/L，28.4 ng/L） than in control group（29.6 mg/L，10.3 ng/L）with significant differences（t=2.042，P=0.044；t=2.137，P=0.038）. Levels of PAC-1 and CD62p were significantly different among three groups（F=7.32，P=0.046；F=5.38，P=0.043）. Levels of PAC-1 and CD62p were significantly different between small volume ACI group（39.9 mg/L，24.5 ng/L） and la－cunar infarction group（45.9 mg/L，29.1 ng/L）（SNK-q＝4.417，4.129；P＝0.031，0.037）. Levels of PAC-1 and CD62p were significantly different between large volume ACI group（53.9 mg/L，33.8 ng/L） and small volume ACI group and lacunar infarction group（SNK-q＝4.216，4.022；P=0.039，0.042）. Conclusions：Significant expressions of PAC-1 and CD62p in patients with ACI can be used to detect the degrees of ACI and are of great importance in preventing and monitoring diseases development.

关键词

急性脑梗死血小板膜糖蛋白纤维蛋白原受体P选择素

Keywords

acute cerebral infarctionplatelet activator combined-1P-selectin

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