Objective：To understand the mortality and death cause sequence of residents from diseases surveillance sites in Chongqing so as to provide scientific references for formulating strategies of disease control. Methods：Based on the data from 8 diseases survei-llance sites and international classification of diseases-10，death causes were classified. Crude mortality，age-standardized mortality and proportion of death causes were calculated. Chi-square test was used to compare rates. Results：Crude mortality of residents from diseases surveillance sites was 667.79/100 000 and age-standardized mortality was 473.39/100 000. Crude mortality of urban was higher than that of rural（?字2=224.89，P<0.001）. Male’s crude mortality was higher than female’s（?字2=572.44，P<0.001）. Crude mortality of aged more than 65 was higher than that of aged 0-14 and aged 15-64（?字2=114 118.60，P<0.001）. The top five death causes were circular system disease（crude mortality was 249.01/100 000，proportion of death cause was 37.29%），tumor（164.36/100 000，24.61%），respiratory system disease（131.27/100 000，19.66%），injury and poisoning（53.78/100 000，8.05%） and digestive system disease（18.42/100 000，2.76%）. Conclusions：Chronic non-communicable diseases are the diseases harming the residents in Chongqing. In order to actively control the harmfulness of chronic non-communicable diseases，all social parts should be mobilized to carry out health education，change the unhealthy life habits and strengthen environmental protection.