Objective：To investigate the scalp nerve block combined with general anesthesia used in craniotomy in patients with hyper－tension，to observe the circulation stability and to explore whether scalp nerve block combined with general anesthesia can reduce the incidence of secondary surgery. Methods：Totally 60 craniotomy patients were randomly divided into the general anesthesia group（control group） and scalp nerve block combined with general anesthesia group（experimental group）. In the experimental group，based on the scope of the incision，the supraorbital，nerve auriculotemporal nerve，greater occipital and lesser occipital selective were selectively blocked. Important vital signs，drug usage，awakening and extubation time and the incidence of related complications during the perioperative period were recorded. Results：Hemodynamic in scalp nerve group is more stable and less volatile during the perioperative period. Dosages propofol（P=0.00），sufentanil（P=0.00） and remifentanil（P=0.00） were higher in experimental group than in control group. Extubation time（P=0.00） and awakening time（P=0.00） were reduced in experimental group than in control group accordingly. Two patients experienced a second surgery in control group（P=0.492） but none in experimental group. Conclusions：Scalp nerve block can more effectively maintain intraoperative heart rate and blood pressure

which may reduce the incidence of secondary surgery.