Objective：To observe the efficacy of psychological intervention combined with Xiaoyao pills in the treatment of liver depression induced irregular menstruation in nursing students in internship. Methods：Totally 48 nursing students met the diagnostic criteria of liver depression induced irregular menstruation were randomly divided into two groups. Patients in control group（n=24） were treated with Xiaoyao pills while those in experimental group（n=24） were treated with psychological intervention combined with Xiaoyao pills. Three months was taken as one treatment course. Improvement in irregular menstruation and mental health after one treatment course in two groups was observed. Results：After one course of treatment，treatment effects were statistically different between two groups（P<0.05）. Before the treatment，there were significant differences in scores of anxiety，inferiority，depression and social withdrawal in two groups compared with those of national norm（P<0.05）；but there was no difference in the scores mentioned above between two groups（P >0.05）. After the treatment，there was no significant differences in scores of anxiety，inferiority，depression and social withdrawal in two groups compared with those of national norm（P >0.05）；but there were differences in scores between experiment group and control group except for the scores of depression and social withdrawal（P<0.05）. Conclusions：Efficacy of psychological intervention combined with Xiaoyao pills in the treatment of liver depression induced irregular menstruation in nursing students in internship is better than that of Xiaoyao pills.