Objective：To observe effects of individualized guidance on compliance of patients with chronic obstructive pulmonary dis－ease（COPD） using noninvasive mechanical ventilation for the first time. Methods：Totally 93 patients with COPD were randomized into control group（n=46） and observation group（n=47）. Patients in control group were treated with traditional routine while those in observation group were implemented by individualized guidance on the basis of conventional treatment. Evaluation was made on com－pliance of patients using noninvasive mechanical ventilation for the first time according to patients’ tolerance to noninvasive ventilator at different time periods，arterial blood gas results，invasive mechanical ventilation rate and duration in ICU. Results：Rate of intubation was 23.91% in control group and hospitalized days in control group were （15.00±2.80） d. Rate of intubation in observation group was 8.51% and hospitalized days in observation group were （9.70±2.10） d. There were significant differences between the two groups（P<0.05）. Conclusions：Individualized instruction helps to improve compliance of patients using noninvasive mechanical ventilation thus to promote noninvasive ventilation rate.