Effects of rasagiline on monoamine oxidase in mouse liver and brain tissues

PENG Yang; ZHANG Wanping; CHENG Peng; ZENG Qingdong; LI Wenjun; LU Zhenhao; YU Yu

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Effects of rasagiline on monoamine oxidase in mouse liver and brain tissues

更新时间：2023-12-18

- Effects of rasagiline on monoamine oxidase in mouse liver and brain tissues
- Journal of Chongqing Medical University Vol. 36, Issue 6, Pages: 577-579(2013)
- 作者机构：
  
  重庆医科大学药学院药物化学教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013，
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PENG Yang, ZHANG Wanping, CHENG Peng, et al. Effects of rasagiline on monoamine oxidase in mouse liver and brain tissues. [J]. Journal of Chongqing Medical University 36(6):577-579(2013)
DOI：

PENG Yang, ZHANG Wanping, CHENG Peng, et al. Effects of rasagiline on monoamine oxidase in mouse liver and brain tissues. [J]. Journal of Chongqing Medical University 36(6):577-579(2013) DOI：

摘要

目的：考察腹腔注射雷沙吉兰对小鼠中肝和脑单胺氧化酶（monoamine oxidase，MAO）活性的抑制作用。方法：采用紫外分光光度法，分别测定低温差速离心法提取小鼠肝和脑组织中的MAO-A和MAO-B活性。结果：雷沙吉兰对MAO-B活性的抑制作用明显强于MAO-A活性；在脑中抑制作用显著比在肝脏中强。结论：雷沙吉兰对小鼠脑内MAO-B活性具有较高的选择性抑制作用。

Abstract

Objective：To investigate the inhibition of rasagiline on monoamine oxidase（MAO） in mouse liver and brain tissues. Methods：After being extracted by differential centrifugation，activities of MAO-A and MAO-B in mouse liver and brain tissues were determined by UV spectrophotometry respectively. Results：Inhibition effect of rasagiline was stronger on MAO-B than on MAO-A and inhibition effect of rasagiline was stronger in the brain than in the liver. Conclusion：Rasagiline exerts selective inhibition effects on MAO-B in mouse liver and brain tissues.

关键词

雷沙吉兰单胺氧化酶小鼠酶活性抑制作用

Keywords

rasagilinemonoamine oxidasemouseenzyme activityinhibition effect

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