Objective：To discuss the efficacy of vitreoretinal surgery using 23-gauge transconjunctival sutureless vitrectomy（TSV） sys－tem for various vitreoretinal diseases. Methods：A total of 154 eyes of patients who underwent vitreoretinal procedures using 23-gauge minimally invasive surgery vitrectomy system in wide field retionscope were enrolled. Efficacy，intraoperative and postoperative compli－cations and operation time were observed. Moreover，intraocular pressure（IOP） and best corrected visual acuity（BCVA） of pre-and post-operation were determined. Results：①All operation were performed successfully. ②Mean duration of operation was （42.0±5.2） min（ranging from 28 min to 83 min）. ③BCVA was improved at 1，2，3 months after operation compared with that before operation. ④Compared with those before operation，both lower and higher IOP were observed on 1 d after operation，higher IOP was observed on 3 d after operation and steady IOP was found on 7 d and 30 d after the operation. ⑤3 eyes（1.9%） had ocular hypotensipon af－ter operation，15 cases（9.7%） had ocular hypertension and no case of endophthalmitis was reported. Conclusion：With the advantages of shorter operation time，less trauma，fewer complications，more convenient and rapid visual recover，23-gauge TSV system is effec－tive in the treatment of vitreoretinal diseases.