Objective：To observe the therapeutic effect of safflower injection on young patients with mild acute cerebral infarction and the effect of safflower injection on serum interleukin（IL）-6 and IL-10 level of these subjects. Methods：Totally 52 patients with mild acute cerebral infarction，aged 35-40 year-old with 10-15 neurological severity score（NSS） were randomly divided into control group（conventional treatment，27 cases） and treatment group（conventional treatment combined with safflower injection 20 ml per day，25 cases）. Morning blood samples of all patients were monitored at three time points（before the treatment，on the 7th d and 14th d during the treatment） and were collected for IL-6 and IL-10 detection using a double antibody sandwich enzyme-linked immunosor－bent assay. Blood samples of healthy people aged 35-40 years were also obtained as controls. Results：NSS of control group and treatment group on the 7th d and 14th d were all significantly decreased compared with those before treatment（all P=0.000）. On the 14th d，NSS of treatment group was lower than that of control group（P=0.040）. Comparing with that before treatment，serum IL-6 level of control group was significantly decreased on the 14th d（P=0.000） but unchanged on the 7th d（P=0.078）. Serum IL-6 levels of treatment group were markedly decreased on the 7th d and 14th d compared with those before treatment（all P=0.000） and control group respectively（P=0.042，P=0.000）. Serum IL-10 levels of control group and treatment group were significantly increased after treating for 7 d and 14 d compared with those before treatment（P=0.000）. On the 7th d and 14th d，serum IL-10 level was higher in treatment group than in control group（P=0.001，P=0.038）. Positive correlation was observed between IL-6/IL-10 value and NSS in treatment group（r=0.997，P=0.048），but not in control group（r=0.962，P=0.177）. Conclusions：Early application of safflower injection is benefit for young patients with mild acute cerebral infarction. The mechanism might be associated with lowing IL-6/IL-10 value through decreasing IL-6 level and increasing IL-10 level.