Comparison of cyclosporine A dose after living related liver transplantation and donation after cardiac death liver transplantation for children
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Comparison of cyclosporine A dose after living related liver transplantation and donation after cardiac death liver transplantation for children
Journal of Chongqing Medical UniversityVol. 38, Issue 12, Pages: 1805-1808(2014)
作者机构:
重庆医科大学附属儿童医院肝胆外科,重庆,400014
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Published:2014,
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Wang Lei, Zhang Mingman, Ren Zhimei, et al. Comparison of cyclosporine A dose after living related liver transplantation and donation after cardiac death liver transplantation for children. [J]. Journal of Chongqing Medical University 38(12):1805-1808(2014)
DOI:
Wang Lei, Zhang Mingman, Ren Zhimei, et al. Comparison of cyclosporine A dose after living related liver transplantation and donation after cardiac death liver transplantation for children. [J]. Journal of Chongqing Medical University 38(12):1805-1808(2014)DOI:
Comparison of cyclosporine A dose after living related liver transplantation and donation after cardiac death liver transplantation for children
Objective:To summarize the usage of cyclosporine A in living related liver transplantation(LRLT) and donation after car-diac death(DCD) liver transplantation for children in our hospital and to provide references for standard dose for children after liver transplantation. Methods:Clinical data of 20 cases of LRLT and DCD liver transplantation during June 2006 to May 2013 in our hos-pital were summarized. These 20 recipients were treated by cyclosporine A-based regimen. Differences in CsA dosage after LRLT and DCD liver transplantation were analyzed. Results:In LRLT group,doses at each time period were:(7-18) mg/(kg·d) at initial peri-od,(7-17.5) mg/(kg·d) at one month after the operation,(7-17.5) mg/(kg·d) at two months after the operation;(5-16) mg/(kg·d) at three months after the operation,(4-13.5) mg/(kg·d) at six months after the operation. In DCD group:(16-20) mg/(kg·d) at initial period,(16-19) mg/(kg·d) at one month after the operation,(13.5-15.5) mg/(kg·d) at two months after the operation,(12.5-15) mg/(kg·d) at three months after the operation,(9-13.5) mg/(kg·d) at six months after the operation. There were statistically signifi-cant difference in the dosage of Cs A between LRLT and DCD liver transplantation(P<0.05). Conclusion:LRLT recipients require less amount of Cs A than DCD recipients during the first six months after receiving liver transplantation with the same drug concen-trations. Large individual difference between the two groups can be observed.
关键词
成人亲属活体供肝移植心脏死亡供肝移植免疫抑制剂环孢素A
Keywords
living related liver transplantationdonation after cardiac death liver transplantationimmunosuppressantcyclosporine A