Preliminary study of effect of docetaxel-loaded lipid microbubbles combined with ultrasound targeted microbubbles destruction on rabbit VX2 cervical lymph node metastatic carcinoma

Wang Ting; Qiu Lihua; Gao Zhi; Li Pan; Zeng Zheng; Ouyang Zilan

您当前的位置：

首页 >

文章列表页 >

Preliminary study of effect of docetaxel-loaded lipid microbubbles combined with ultrasound targeted microbubbles destruction on rabbit VX2 cervical lymph node metastatic carcinoma

更新时间：2023-12-18

- Preliminary study of effect of docetaxel-loaded lipid microbubbles combined with ultrasound targeted microbubbles destruction on rabbit VX2 cervical lymph node metastatic carcinoma
- Journal of Chongqing Medical University Vol. 38, Issue 5, Pages: 710-714(2014)
- 作者机构：
  
  1. 重庆医科大学附属口腔颌面外科口腔医院口腔疾病与生物医学重庆市重点实验室,重庆,401147
  2. 重庆医科大学附属第二医院口腔科,重庆,400016
  3. 重庆医科大学超声影像学研究所,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2014，
扫描看全文
Wang Ting, Qiu Lihua, Gao Zhi, et al. Preliminary study of effect of docetaxel-loaded lipid microbubbles combined with ultrasound targeted microbubbles destruction on rabbit VX2 cervical lymph node metastatic carcinoma. [J]. Journal of Chongqing Medical University 38(5):710-714(2014)
DOI：

Wang Ting, Qiu Lihua, Gao Zhi, et al. Preliminary study of effect of docetaxel-loaded lipid microbubbles combined with ultrasound targeted microbubbles destruction on rabbit VX2 cervical lymph node metastatic carcinoma. [J]. Journal of Chongqing Medical University 38(5):710-714(2014) DOI：

摘要

目的：初步探讨载多西紫杉醇脂质微泡（docetaxel-loaded lipid microbubbles，DLLM）联合超声靶向微泡破裂（ultrasound targeted microbubbles destruction，UTMD）对兔VX2舌癌颈部淋巴转移瘤的治疗作用。方法：成功建立兔VX2舌癌颈部淋巴转移瘤动物模型30只，随机分为A组、B组、C组、D组、E组、F组（n=5）：A组为单纯药物组、B组为单纯载药微泡组、C组为药物+超声组、D组为单纯微泡+超声组、E组为载药微泡+超声组、F组为对照组。治疗前后用超声测量各组动物颈部淋巴转移瘤大小，计算瘤体体积和抑瘤率；比较各组动物颈部淋巴转移瘤组织中CD34、微血管密度（microvessel density，MVD）及血管内皮生长因子（vascular endothelial growth factor，VEGF）的表达。结果：E组实验动物颈部淋巴转移瘤的抑瘤率高于其他组（P<0.05），与其他各组相比差异有统计学意义；E组实验动物颈部淋巴转移瘤中CD34表达水平最低，MVD、VEGF表达水平显著低于其他各组（P<0.01）与其他各组相比差异有统计学意义。结论：DLLM联合UTMD不仅能在宏观表现上抑制兔VX2舌癌颈部淋巴转移瘤生长，更能一定程度上从分子生物学水平明显抑制兔VX2 舌癌颈部淋巴转移瘤的转移、生长。

Abstract

Objective：To study the treatment effect of docetaxel-loaded lipid microbubbles（DLLM） combined with ultrasound targeted microbubbles destruction（UTMD） on rabbit VX2 cervical lymph node metastatic carcinoma. Methods：Thirty rabbit VX2 cervical lymph node metastatic carcinoma model were successfully established and were randomly divided into 6 groups（A group，B group，C group，D group，E group，F group，n=5）. A group used docetaxel，B group used DLLM，C group used docetaxel + UTMD，D group used lipid microbubbles + UTMD，E group used DLLM +UTMD and F group was control group. Volume and inhibition rate of cervical lymph node metastatic carcinoma in each group before and after the treatment were detected and compared. Expression of CD34 and microvessel density（MVD） and vascular endothelial growth factor（VEGF） was compared among different groups. Results：After the treatment，inhibition rate was higher in E group than in other groups（P<0.05） and the expression of CD34 and MVD and VEGF was significantly lower in E group than in other groups（P<0.01）. Conclusions：DLLM combined with UTMD can inhibit the growth of the cervical lymph node metastatic carcinoma from the macroscopic view.Furthermore，it can inhibit the growth of the cervical lymph node metastatic carcinoma from the molecular level.

关键词

兔颈部淋巴转移瘤多西紫杉醇微泡

Keywords

rabbitthe cervical lymphtic metastasisdocetaxelmicrobubbles

references

Views

411

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Determination of levofloxacin concentration in rabbit tibia and bone marrow by HPLC

In vivo imaging and preliminary treatment experiments of docetaxel-loaded ultrasound microbubbles decorated with TATp and SDF-1 agents

A study on the method of orthotopic transplantation VX₂ in rabbit uterine corpus

Establishment of transplantable malignant bone tumor model and observation of its biological features in rabbit

Research on establishing of rabbit VX2 carcinoma model and monitoring with color Doppler energy ultrasound technique

Related Author

Wang Qi

Huang Wei

Liang Xi

Hu Ning

Zhou Nian

Zhao Chen

Sun Zexu

Yu Chao

Related Institution

Institute of Life Science,Chongqing Medical University

Department of Orthopedics,The First Affiliated Hospital of Chongqing Medical University

Institute of Ultrasound Imaging,Chongqing Medical University

Chongqing Collaborative Innovation Center For Functional Food,Chongqing University of Education

Department of Stomatology,the Second Affiliated Hospital,Chongqing Medical University

⁰