Objective：To detect the expression of vimentin（VIM）in myocardium and to explore the characteristics of myocardial injuries caused by epilepsy. Methods：Models of epileptic rats were established by intraperitoneal injection of pentylenetetrazol. Expression of VIM in myocardium of epileptic rats was examined by pathologic，immunohistochemistry，and Western blot methods. Results：Hemorrhagic and hypoxic ischemic changes were showed in myocardiums of epileptic groups. With the extended duration of epilepsy，and the increases of frequency and time of seizures，there was a trend of aggravation of myocardial necrosis，fibroblast proliferation，as well as a remarkable up-regulation of VIM. Conclusion：Epilepsy can cause myocardial injury and promote the expression of VIM in myocardium.