Logistic regression analysis of clomiphene citrate resistance in females with polycystic ovarian syndrome

LiuYan; Li Cong; Wang Lianlian

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Logistic regression analysis of clomiphene citrate resistance in females with polycystic ovarian syndrome

更新时间：2023-12-18

- Logistic regression analysis of clomiphene citrate resistance in females with polycystic ovarian syndrome
- Journal of Chongqing Medical University Vol. 38, Issue 11, Pages: 1542-1545(2014)
- 作者机构：
  
  1. 武警重庆总队医院妇产科,重庆,400061
  2. 重庆医科大学附属第一医院妇产科,重庆,400016
  3. 重庆医科大学附属第一医院生殖健康与不孕专科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2014，
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LiuYan, Li Cong, Wang Lianlian. Logistic regression analysis of clomiphene citrate resistance in females with polycystic ovarian syndrome. [J]. Journal of Chongqing Medical University 38(11):1542-1545(2014)
DOI：

LiuYan, Li Cong, Wang Lianlian. Logistic regression analysis of clomiphene citrate resistance in females with polycystic ovarian syndrome. [J]. Journal of Chongqing Medical University 38(11):1542-1545(2014) DOI：

摘要

目的：通过对克罗米芬（clomiphene citrate，CC）抵抗的多囊卵巢综合征（plycystic ovary syndrome，PCOS）患者相关危险因素的logistic回归分析，探讨临床上难治性PCOS诊疗的思路和策略。方法：92例PCOS患者分为CC有效组和CC抵抗组，均测其体质量、身高、年龄、葡萄糖耐量实验（glucose tolerance test，OGTT）（0’、120’）、胰岛素（insulin）（0’、120’）、卵泡刺激素（fol－licule-stimulating hormone，FSH）、黄体生成素（luteinizing hormone，LH）、睾酮（testosterone，T）、雌二醇（estradiol，E2）以及同型半胱氨酸（homocysteine，Hcy），并计算体质指数（body mass index，BMI）和稳态模式评估法测定胰岛素抵抗指数（homeostasis model assessment for insulin resistance，HOMA-IR）。将差异有统计学意义的指标进行logistic回归分析以及ROC曲线分析。结果：CC抵抗组与CC有效组之间比较，年龄（P=0.000）、BMI（P=0.005）、Hcy（P=0.000）、OGTT（0’）（P=0.000）、INS（0’）（P=0.014）、T（P=0.042）、HOMA-IR（P=0.000）差异有统计学意义；Hcy、OGTT（0’）、INS（0’）、T、HOMA-index、BMI、年龄指标与CC抵抗呈负相关；Hcy的ROC曲线下面积为0.981，95%CI=0.972～0.990。结论：Hcy在预测难治性CC抵抗的PCOS中是１项最佳的危险预测指标。

Abstract

Objective：To discuss the strategies for treating refractory plycystic ovary syndrome（PCOS） by risk factors logistic regression analysis in clomiphene citrate（CC） resistant PCOS patients. Methods：A total of 92 PCOS patients were divided into CC resistant group and CC effective group. Patients' weight，height，age，glucose tolerance test（OGTT）（0’，120’），insulin（0’，120’），follicle-stimulating hormone（FSH），luteinizing hormone（LH），testosterone（T），estradiol（E2） and homocysteine（Hcy） were measured；the body mass in－dex（BMI） and homeostasis model assessment for insulin resistance（HOMA-IR） were calculated. The statistically significant differ－ence was analyzed by logistic regression analysis and ROC curve analysis. Results：There were statistically significant differences in age（P=0.000），BMI（P=0.005），Hcy（P=0.000），OGTT（0’）（P=0.000），INS（0’）（P=0.014），T（P=0.042），HOMA-index（P=0.000） be－tween CC resistant group and CC effective group. Hcy，OGTT（0’），INS（0’），T，HOMA-index，BMI，and age were negatively correlat－ed with CC resistance.The area under ROC curve was 0.981 Hcy，95%CI=0.972-0.990. Conclusion：Hcy is the best risk predictors in predicting CC resistant of refractory PCOS.

关键词

克罗米芬多囊卵巢综合征同型半胱氨酸logistic回归分析

Keywords

clomiphene citrateplycystic ovary syndromehomocysteinelogistic regression analysis

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