The occurrence and development of chronic kidney disease（CKD） hypertension is closely related with sympathetic over activity. The anti-hypertensive drugs and anti-sympathetic antihypertensive treatment program are difficult to achieve the target of anti-hypertension. In recent years，catheter-based renal sympathetic denervation technique is developing rapidly，which becomes a novel method to treat resistant hypertension of CKD patients. This paper aims to review the recent progress in this technique