Association between atrial fibrillation and atrial ion channels remodeling induced by aging

Wang Luzhen; Ou Xianhong; Zeng Xiaorong

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Association between atrial fibrillation and atrial ion channels remodeling induced by aging

更新时间：2023-12-18

- Association between atrial fibrillation and atrial ion channels remodeling induced by aging
- Journal of Chongqing Medical University Vol. 38, Issue 10, Pages: 1351-1354(2014)
- 作者机构：
  
  泸州医学院心血管医学研究所医学电生理实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2014，
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Wang Luzhen, Ou Xianhong, Zeng Xiaorong. Association between atrial fibrillation and atrial ion channels remodeling induced by aging. [J]. Journal of Chongqing Medical University 38(10):1351-1354(2014)
DOI：

Wang Luzhen, Ou Xianhong, Zeng Xiaorong. Association between atrial fibrillation and atrial ion channels remodeling induced by aging. [J]. Journal of Chongqing Medical University 38(10):1351-1354(2014) DOI：

摘要

心房颤动（atrial fibrillation，AF），简称房颤，是临床上最为常见的快速性心律失常之一，尤其多见于老年人。年龄一直被认为是AF发生的重要危险因素之一。大量研究发现，心房重构（atrial remodeling，AR）是增龄性AF得以发生和维持的重要因素，心房肌细胞相关离子通道电流的变化及其通道蛋白、基因表达的变化在心房电重构（atrial electrial remodeling，AER）中起重要作用。本文就增龄引起心房离子通道重构与AF的关系予以综述。

Abstract

Atrial fibrillation（AF） is one of the most common clinical tachyarrhythmia，which is seen most frequently in the elderly. Ag－ing is regarded as an important risk factor for AF. A lot of researchers find that atrial remodeling plays an important role in occurrence and maintenance of the age-related AF. The changes of ion channel currents and its channel protein or gene expression in atrial my－ocytes are related to occurrence of atrial remodeling. This paper made a review on the recent studies of the relationship between AF and the changes which leaded by aging in atrial remodeling and ion channels.

关键词

心房颤动增龄心房重构离子通道

Keywords

atrial fibrillationagingatrial remodelingion channels

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