Preliminary research on drug release in vitro and pharmacokinetics in vivo of pyridostigmine bromide nanoemulsion

Chen Xueliang; Zhao Jing; Zhao Hua; Zhang Xin; Zhang Jingqing

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Preliminary research on drug release in vitro and pharmacokinetics in vivo of pyridostigmine bromide nanoemulsion

更新时间：2023-12-22

- Preliminary research on drug release in vitro and pharmacokinetics in vivo of pyridostigmine bromide nanoemulsion
- Journal of Chongqing Medical University Vol. 43, Issue 1, Pages: 139(2018)
- 作者机构：
  
  重庆医科大学重庆高校药物工程研究中心,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2018，
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Chen Xueliang, Zhao Jing, Zhao Hua, et al. Preliminary research on drug release in vitro and pharmacokinetics in vivo of pyridostigmine bromide nanoemulsion. [J]. Journal of Chongqing Medical University 43(1):139(2018)
DOI：

Chen Xueliang, Zhao Jing, Zhao Hua, et al. Preliminary research on drug release in vitro and pharmacokinetics in vivo of pyridostigmine bromide nanoemulsion. [J]. Journal of Chongqing Medical University 43(1):139(2018) DOI：

摘要

目的：对溴吡斯的明纳米乳（pyridostigmine bromide nanoemulsion，PBNE）在体外的释放行为和体内的药动学行为进行初步研究。方法：建立高效液相色谱法考察体外释放行为和体内药动学行为。结果：PNBE与溴吡斯的明（pyridostigmine bro－mide，PB）在4种释放介质（pH1.2的盐酸溶液，pH6.8、pH7.4、pH7.8的磷酸缓冲溶液）中的体外释放行为相似，PBNE的MRT（0-24 h）值较PB增加0.98 h，PBNE的Cmax值是PB的1.55倍，PBNE的口服生物利用度是PB的1.82倍。结论：PBNE在不同介质中的体外释药行为相似，PBNE可改变体内的药动学行为，其口服生物利用度比PB好，PBNE具有一定的缓释作用。

Abstract

Objective：To explore the drug release behaviors in vitro and pharmacokinetics in vivo of pyridostigmine bromide na－noemulsion（PBNE）. Methods：The high performance liquid chromatography was established to investigate the release behaviors in vitro and pharmacokinetic behaivors in vivo. Results：The release behaviors of PBNE in 4 media（pH1.2 HCl，pH6.8 PBS，pH7.4 PBS，pH7.8 PBS） was similar to those of pyridostigmine bromide（PB）. The MRT（0-24 h） of PBNE increased by 0.98 h than PB；the Cmax of PBNE was 1.55 times that of PB；the oral bioavailability of PBNE was 1.82 times that of PB. Conclusion：The release behaviors of PBNE in different release medium are similar in vitro. PBNE can change the pharmacokinetic behaviors in vivo；the oral bioavailabil－ity of PBNE is higher than PB and PBNE has a sustained-release effect in vivo.

关键词

溴吡斯的明纳米乳体外释放药代动力学

Keywords

pyridostigmine bromidenanoemulsionin vitro releasepharmacokinetics

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