Objective：To investigate the effect of preterm combined with premature rupture of membranes（PPROM） on maternal and preterm infants by observing the pregnancy outcome of pregnant women with PPROM. Method：Totally 91 pregnant women with PPROM in our department of obstetrics and gyne－cology from Jul，2013 to Jun，2014 were enrolled as study group. Meanwhile，89 women of premature delivery without rupture of membranes were selected as control. The pregnancy outcome of the two groups were compared. Results：In study group，cesarean section rate was 68.1%（62/91），and the rate of postpartum hemor－rhage was 8.8% （8/91）. In control group，rates of cesarean section and postpartum hemorrhage were 21.3%（19/89） and 1.1%（1/89）. For the outcome of newborn，rates of fetal distress，neonatal pneumonia，neonatal asphyxia and low-birth weight were 50.5%（46/91），7.7%（7/91），9.9%（9/91） and 14.3%（13/91） in study group，while were 9.0%（8/89），1.1%（1/89），2.2%（2/89） and 5.0%（4/89） in control group. The adverse event rate was significantly higher in study group than in control group，including cesarean section，post－partum hemorrhage，fetal distress，and the incidence of low body weight（P<0.05）. Conclusion：PPROM is obviously harmful for preg－nancy woman and newborn，which we need take positive strategy to prevent and handle with.