Objective：To observe the clinical efficacy and the adverse effects of ultra-pulse CO2 laser in the treatment of the children’s pyogenic granuloma. Methods：Following the voluntary principle，the 120 patients with pyogenic granuloma were treated by traditional CO2 laser as control group；the 103 patients with pyogenic granuloma were treated by ultra-pulse CO2 laser as treated group. Accord－ing to the voluntary principle，the treatment effect and the adverse effects were evaluated at 1 month，3 months，6 months，12 months postoperatively. Results：The effective rate in the treatment group was 97.1%，while that in the control group was 96.7%，without sig－nificant differences between two groups（P >0.05）. Among 120 cases in the control group，26 cases had adverse effects，including mild scar（14 cases），pigmentation（5 cases），pigment loss（4 cases），and erythema（3 cases）. Among 103 cases in the treatment group，10 cases had adverse effects，including mild scar（3 cases），pigmentation（3 cases），pigment loss（2 cases），and erythema（2 cases）. The incidence of adverse effects between two groups had significant differences（P<0.05）. Conclusion：Application of the ultra-pulse CO2 laser in treatment of the pyogenic granuloma has better clinical efficacy，with good safety profile than the traditional treatment.