Objective：To observe the clinical curative effect of good patient management（GPM） and the changes of patients’ sleep-wake rhythm before and after treatment. Methods：The data of 264 patients who accepted treatment during June 2012 to May 2014 in the Ninth People’s Hospital of Zhengzhou city and Henan Province People’s Hospital were collected. They were divided into 2 groups randomly，one group accepted GPM while the other received symptomatic treatment. Degree of pain was scored by numeric rating scale（NRS） respectively before and at one week after GPM or symptomatic treatment. The results were analyzed with statistics. The results of 24-hour sleep monitoring of 30 randomly selected cases were recorded before and after treatment respectively. Then the sleep-wake rhythm based on electroencephalogram，electromyogram and electronystagmogram was analyzed. The total sleep time，the time of light sleep，deep sleep and rapid eye move（REM） sleep were recorded and analyzed statistically. Results：GPM can signifi－cantly relieve pain，reduce the NRS score，prolong total sleep time and REM sleep time，raise the proportion of light sleep and REM sleep in total sleep time，but symptomatic treatment can’t. Conclusion：GPM could relieve cancer pain，prolong sleep time，improve sleep-wake rhythm and sleep quality.