Objective：To investigate the relation between youth serum lipoprotein-associated phospholipase A2 levels and insulin re－sistance and its clinical significance. Methods：One hundred and sixty subjects were enrolled into this study，including 87 women and 73 men with an average age of （33.4±1.2） years. Anthropometric indicators such as height，weight and biochemical markers such as serum lipid profile，plasma glucose，and serum insulin level were examined. ELISA was used to detect serum lipoprotein-associat－ed phospholipase A2（Lp-PLA2） levels. According to body mass index（BMI） and the results of oral glucose tolerance test（OGTT），we recruited 65 cases of normal weight-normal glucose tolerance（NW-NGT），45 cases of overweight-obesity-normal glucose tolerance （OB-NGT） and overweight-obesity-type 2 diabetes（OB-T2DM） in total. Results：The OB-NGT group and OB-T2DM group had higher Lp-PLA2，homeostasis model assessment-insulin resistance index（HOMA-IR），BMI，low density lipoprotein-cholesterol（LDL-C），fasting insulin（FINS） and high sensitivity C-reactive protein（hs-CRP） levels compared with those of NW-NGT group（all P＜0.05）. As was shown by Pearson correlation analysis，HOMA-IR had a significantly positive correlation with serum Lp-PLA2 level，BMI，hs-CRP and waistline. Multiple linear stepwise regres－sion analysis statistics indicated that HOMA-IR was the inde－pendent factor of serum Lp-PLA2 level（t=4.201，P=0.000）. In addition，we used Youden’s index（YI） to determine the best threshold. YI got its maximum value，when Lp-PLA2 level was 21.0 ng/ml，which therefore was thought to be the best cut-off point for diagnosis of insulin resistance. Conclusion：Increased youth serum Lp-PLA2 level is closely related to insulin resistance，At the same time serum Lp-PLA2 is an independent risk factor of insulin resis－tance，which provides a certain clinical value in predicting the occurrence of insulin resistance.