Relevance of the chemokine CXCL12/CXCR7 axis in cardiovascular disease

Tu Xiaoli; Wu Yanqing

您当前的位置：

首页 >

文章列表页 >

Relevance of the chemokine CXCL12/CXCR7 axis in cardiovascular disease

更新时间：2023-12-18

- Relevance of the chemokine CXCL12/CXCR7 axis in cardiovascular disease
- Journal of Chongqing Medical University Vol. 40, Issue 4, Pages: 481-484(2015)
- 作者机构：
  
  南昌大学第二附属医院心血管内科
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2015，
扫描看全文
Tu Xiaoli, Wu Yanqing. Relevance of the chemokine CXCL12/CXCR7 axis in cardiovascular disease. [J]. Journal of Chongqing Medical University 40(4):481-484(2015)
DOI：

Tu Xiaoli, Wu Yanqing. Relevance of the chemokine CXCL12/CXCR7 axis in cardiovascular disease. [J]. Journal of Chongqing Medical University 40(4):481-484(2015) DOI：

摘要

趋化因子CXCL12 （chemokine CXCL12，CXCL12）是一种能诱导细胞向高浓度方向定向运动的小分子多肽类物质，研究表明其能够通过调节造血干细胞、祖细胞的归巢、迁移及动员至外周环境，来保护组织在损伤刺激下的自我稳态。既往研究认为CXCL12的唯一受体是趋化因子受体4（C-X-C chemokine receptor 4，CXCR4），但研究表明其还存在另一个受体：趋化因子受体7（C-X-C chemokine receptor 7，CXCR7），它是一个非典型趋化因子受体家族，且不是通过激活G蛋白偶联受体而是通过与β抑制蛋白类相互作用，调节CXCL12的生物利用率以及上调或者下调CXCR4介导的活性及信号通路。本文主要讨论CXCR7在细胞增殖、血管生成、及细胞迁移方面的作用，以及其与心血管疾病之间的相关性。

Abstract

Objective：Chemokine receptor CXCL12 is a small protein that mediates cell chemotaxis. Previous studies confirmed that chemokine receptor CXCL12 was a principal regulator of homing，migration and mobilization of haematopoietic stem cells and endothelial pro－genitor cells（EPCs） during steady-state homeostasis and injury. Once previously thought to interact exclusively with CXCR4，CXCL12 also binds to CXCR7（recently renamed ACK3R），which belongs to an atypical chemokine receptor family whose members fail to ac－tivate G proteins but interact with β-arrestins，control the CXCL12 bioavailability，enhance or dampen CXCR4- mediated signaling and activity.Here we discuss the role of CXCR7 in cell proliferation，angiogenesis，and metastasis，with a focus on cardiovascular dis－ease.

关键词

趋化因子CXCL12趋化因子受体7心血管疾病

Keywords

chemokine CXCL12C-X-C chemokine receptor 7cardiovascular disease

references

Views

879

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Nutrient deprivation induced autophagy mechanism and the regulation on cardiovascular disease

Effects of hormone replacement therapy to lipid in postmenopausal women: A systemic review

AN OBSERVATION ON OF CHANGE OF ECG FOR PATIENTS WITH PRESENT ABNORMAL ECG IN ESWL

Analysis of disease constitution and death cause of 10 308 hospitalized patients with cardiovascular diseases

Research advances of effect of morning blood pressure surge on target organ damage

Related Author

Wei Hongchang

Lü rong

Cao Tongtong

Zhang Liwei

Wang Yuting

Shen Jing

Liu Yuan

郑光天

Related Institution

Department of Pathlolgy,Shanghai University of Traditional Chinese Medicine

School of Public Health and Management,Center for Research of Medicine and Social Development,the Innovation Center for Social Risk Governance in Health,Chongqing Medical University

重庆医科大学第二医院麻醉科

重庆医科大学碎石中心

Department of Cardiology

⁰