Objective：To investigate the effect of different doses of statins on blood lipid levels and safety of young and middle-aged coronary heart disease patients after coronary stent implantation. Methods：Retrospective analysis on the young and middle-aged pa－tients who had coronary stent implantation in our department from December 2013 to June 2014 was conducted. Totally 81 patients received rosuvastatin at the dose of 10 mg/d and 87 received rosuvastatin at the dose of 20 mg/d. After the treatment of 6 to 8 weeks，the changes of levels of total cholesterol（TC），triglyceride（TG），low density lipoprotein cholesterol（LDL-C），high density lipoprotein cholesterol（HDL-C），alanine transaminase（ALT），aspartate transaminase（AST），hypersensitive3 C-reactive protein（hs-CRP），Crea－tine Kinase（CK）and adverse reaction rate were compared between the two groups before and after treatment. Results：After the treat－ment of 6 to 8 weeks，significant declines were found in the levels of TC，TG，LDL-C，hs-CRP both in the two groups. HDL-C was significantly higher after the treatment. The changes in the levels of TC LDL-C and hs-CRP in high-intensity rosuvastatin group were significantly higher than those of moderate-intensity rosuvastatin group，with statistical significances. No patient experienced the ab－normal transaminase and abnormal muscle enzymes. Conclusion：For the young and middle-aged patients after coronary stent im－plantation，high-intensity statin（20 mg rosuvastatin） is more effective and safe than moderate-intensity statin（10 mg rosuvastatin），and has good safety.