Objective：To explore the clinical effect of ultrasound-guided transverses abdominis plane（TAP） block combined with in－travenous anesthesia in laparoscopic gastrointestinal surgery. Methods：Patients of 84 with laparoscopic gastrointestinal surgery were selected and divided into two groups according to the random number table method. The control group was treated with total intra－venous anesthesia，while the observation group was treated with ultrasound-guided TAP block on the basis of the control group. The visual analogue scale（VAS） score，postoperative recovery and adverse reaction were compared and analyzed. Results：VAS scores at 1，4，8，12 and 24 h in the observation group was significantly lower than those in the control group（P<0.05）. After the operation of 48 h，the first remedy pain time（11.67±1.23） h in the observation group was significantly longer than that in the control group （4.32±1.21） h，with statistically significant difference（t=27.607，P=0.025）. After 48 h of operation，the recovery time of the gastroin－testinal tract was without significant difference in both two groups（P>0.05）. As for pain in right shoulder，there were 12 patients （28.57%） in the observation group and 16 patients（38.10%） in the control group，without significant difference（ χ2=0.857，P=0.355）. None of the patients had adverse reactions such as respiratory depression，skin itching，vomiting，nausea and mental disorders. Conclusion：Implementing the full-time intravenous anesthesia combined with ultrasound-guided TAP block in the laparoscopic gas－trointestinal surgery can effectively reduce postoperative pain and prolong the first remedy analgesia time，with clinical pro－motion value.