Cytogenetic change and clinical significance of plasma cell dyscrasia in Chongqing region

Zhang Ping; Bai Fengxia; Luo Yun; Lou Shifeng

您当前的位置：

首页 >

文章列表页 >

Cytogenetic change and clinical significance of plasma cell dyscrasia in Chongqing region

更新时间：2023-12-18

- Cytogenetic change and clinical significance of plasma cell dyscrasia in Chongqing region
- Journal of Chongqing Medical University Vol. 40, Issue 4, Pages: 538-541(2015)
- 作者机构：
  
  重庆医科大学附属第二医院血液科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2015，
扫描看全文
Zhang Ping, Bai Fengxia, Luo Yun, et al. Cytogenetic change and clinical significance of plasma cell dyscrasia in Chongqing region. [J]. Journal of Chongqing Medical University 40(4):538-541(2015)
DOI：

Zhang Ping, Bai Fengxia, Luo Yun, et al. Cytogenetic change and clinical significance of plasma cell dyscrasia in Chongqing region. [J]. Journal of Chongqing Medical University 40(4):538-541(2015) DOI：

摘要

目的：探讨间期荧光原位杂交（fluorescence in situ hybridization，FISH）检测重庆地区浆细胞病患者遗传学变化及其临床意义。方法：采用组合探针（D13S319/RB1、CCND1/IgH、p53、CKS1B/CDKN2C）对50例浆细胞病患者骨髓进行FISH检测，分析其分子遗传学异常，同时行常规染色体检查，并比较其与临床指标的相关性。结果：50例患者采用FISH检测，有34例（68％）检测出分子遗传学异常，24例（48%）检出1种异常，10例（20％）同时检测出2种及以上异常。其异常比例从高到低分别为：IgH 基因异位（36％），13号染色体缺失（24％）和 p53 基因丢失（20％）；常规染色体检查只有6例患者（12%）发现染色体结构异常。遗传学异常检出与患者性别、年龄、临床类型及分期无关。结论：FISH较常规染色体检查更易发现异常；IgH 基因异位、13q14缺失及p53 基因丢失在重庆地区浆细胞病中发生率较高，p53 基因丢失及13q14 缺失与近期预后无明确关系。

Abstract

Objective：To investigate the cytogenetic abnormalities of patients with plasma cell dyscrasias by fluorescence in situ hy－bridization（FISH） in Chongqing region and its clinical significance. Methods：Panel probes of D13S319/RB1，CCND1/IgH，p53 and CKS1B/CDKN2C were used to detect the chromosomal abnormalities in 50 patients with plasma cell dyscrasias. At same time the con－ventional chromosome check was done. The correlation of cytogenetic abnormalities with clinical feature was studied. Results：Molec－ular genetics change was found in 34 cases（68%） out of 50 cases. One kind of abnormity was found in 24 cases（48%） and two or more than two kinds of abnormity was found in 10 cases（20%）. The ratio of abnormity form high to low was as followed：IgH gene aber－rance（36%），13q deletion（24%） and P53 gene deletion（20%）. Only 6 cases（12%） were found chromosome structural abnormalities by conventional chromosome check. The genetics abnormality was not correlated with age，gender，subgroup and stage. Conclusion：FISH method can more easily find abnormity than conventional chromosome check. High incidence of IgH gene aberrance，13q and P53 gene deletion is find among patients with plasma cell dyscrasias in Chongqing region，nevertheless，having no association with recent prognosis.

关键词

多发性骨髓瘤荧光原位杂交分子遗传学

Keywords

multiple myelomafluorescence in situ hybridizationmolecular genetics

references

Views

854

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Application of Morphogo in the detection of minimal residual disease in multiple myeloma

PCDH10 prevents multiple myeloma cell escape from epirubicin-induced cytotoxicity

Autologous peripheral blood stem cell transplantation with tandem transfusion of stem cells in treating hematological malignant disease-A report of 4 cases

MRI features and differential diagnosis of multiple myeloma in the vertebra

Related Author

Siheng Liu

Jia Li

Xiangui Peng

Cheng Zhang

Yang Zesong

Xu Yonghui

Chen Jianbin

Yuan Haiting

Related Institution

Hematology Medical Center，Xinqiao Hospital，Army Medical University

Department of Hematology,The First Affiliated Hospital of Chongqing Medical University

Department of Hematology,the Second College of Clinical Medicine,Chongqing Medical University

重庆医科大学第二临床学院血液科

Department of Radiology,the First Affiliated Hospital,Chongqing Medical University

⁰