Objective：To investigate the correlation of clinical characteristics of migraine with metabolic syndrome（MS） and its com－ponents. Methods：Totally 212 migraineurs were recruited in the neurology clinic department. A questionnaire survey was used to col－lect the clinical characteristics of migraine headache and its concomitants，such as analgesic use，psychiatric disorders and disability. The anthropometric measurements and blood biochemistry were measured for the diagnosis of MS，and Transcranial Doppler sonography was conducted for intracranial vascular function. Results：Of 212 migraine patients，145 cases（68.4%） had one and more metabolic abnormalities and 22 cases（10.4%） had MS. Single factor analysis results showed metabolic abnormalities in migraine patients were associated with age，duration of migraine attack，body mass index and waist-to-height ratio（P=0.007，0.008，0.000 and 0.000，respective－ly）. Multivariate logistic regression analysis showed analgesic-overuse was the main risk factor of MS in migraine patients（OR=4.320，P=0.042）. Conclusion：The prevalence of MS in migraine patients is associated with analgesic-overuse. Rational use of analgesics may lower the risk for MS and cardiovascular disease in migraine patients.