Effect of cervical Luschka joint degenerative change on expression of VEGF and its receptor

CHEN Jie; LI Kun; ZHANG Shao-jie; LI Xiao-he; GAO Shang; WANG Hai-yan; LI Zhi-jun; MA Yuan; ZHAO Dan-yang; SHI Jun; WANG Xing

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Effect of cervical Luschka joint degenerative change on expression of VEGF and its receptor

Basic Research | 更新时间：2023-12-13

- Effect of cervical Luschka joint degenerative change on expression of VEGF and its receptor
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 32, Issue 12, Pages: 1025-1028(2023)
- 作者机构：
  
  1.内蒙古医科大学基础医学院人体解剖学教研室，内蒙古呼和浩特 010110
  2.内蒙古医科大学基础医学院数字医学中心，内蒙古呼和浩特 010110
  3.内蒙古医科大学基础医学院生理学教研室，内蒙古呼和浩特 010110
- 作者简介：
- 基金信息：
- DOI：
  CLC： R322
- Published：25 December 2023，
  
  Received：29 December 2022，
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陈杰,李琨,张少杰等.颈椎钩椎关节退行性变对VEGF及其受体表达的影响[J].局解手术学杂志,2023,32(12):1025-1028.

CHEN Jie,LI Kun,ZHANG Shao-jie,et al.Effect of cervical Luschka joint degenerative change on expression of VEGF and its receptor[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(12):1025-1028.
陈杰,李琨,张少杰等.颈椎钩椎关节退行性变对VEGF及其受体表达的影响[J].局解手术学杂志,2023,32(12):1025-1028. DOI：

CHEN Jie,LI Kun,ZHANG Shao-jie,et al.Effect of cervical Luschka joint degenerative change on expression of VEGF and its receptor[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2023,32(12):1025-1028. DOI：

摘要

目的

探讨颈椎退行性变对血管内皮生长因子（VEGF）及血管内皮生长因子受体-2(VEGFR-2)表达的影响。

方法

取成年尸体双侧健康颈椎C

节段为对照组，取成年尸体双侧退行性变颈椎C

节段为实验组。通过免疫组织化学、免疫荧光染色技术及实时定量PCR观察并分析2组VEGF及VEGFR-2表达的变化。

结果

实验组VEGF及VEGFR-2的蛋白和mRNA表达均高于对照组，差异有统计学意义（

0.05）。

结论

颈椎钩椎关节退行性变显著上调VEGF及VEGFR-2的表达，与类关节结构退变引发的钩椎关节周围微环境改变密切相关。

Abstract

Objective

To observe the effect of cervical degenerative change on the expression of vascular endothelial growth factor （VEGF） and vascular endothelial growth factor receptor-2 （VEGFR-2）.

Methods

The C

to C

segments of bilateral healthy cervical vertebrae of adult cadavers were taken as the control group， and the C

to C

segments of bilateral degenerative cervical vertebrae of adult cadavers were taken as the experimental group. The expression changes of VEGF and VEGFR-2 of the two groups were observed and analyzed by

immunohistochemistry， immunofluorescence staining and real-time quantitative PCR.

Results

The protein and mRNA expressions of VEGF and VEGFR-2 in the experimental group were higher than those in the control group， with statistically significant differences

（

0.05）.

Conclusion

Cervical Luschka joint degenerative change significantly up-regulates the expression of VEGF and VEGFR-2， which is closely related to the microenvironmental changes around the Luschka joint caused by degeneration of joint-like structure.

关键词

颈椎钩椎关节退行性变VEGFVEGFR-2

Keywords

cervical vertebraLuschka jointdegenerative changeVEGFVEGFR-2

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