Multivariate analysis and establishment of diagnostic model for delayed graft function in kidney transplantationd
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Multivariate analysis and establishment of diagnostic model for delayed graft function in kidney transplantationd
Journal of Clinical Ultrasound in MedicineVol. 25, Issue 5, (2023)
作者机构:
1. 南方医科大学研究生院
2. 佛山市第一人民医院
3. 南方医科大学顺德医院
作者简介:
基金信息:
DOI:
CLC:
Published:2023,
Published Online:26 May 2023,
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Multivariate analysis and establishment of diagnostic model for delayed graft function in kidney transplantationd. [J]. Journal of Clinical Ultrasound in Medicine 25(5).(2023)
DOI:
Multivariate analysis and establishment of diagnostic model for delayed graft function in kidney transplantationd. [J]. Journal of Clinical Ultrasound in Medicine 25(5).(2023)DOI:
Multivariate analysis and establishment of diagnostic model for delayed graft function in kidney transplantationd
Objective To investigate the application value of multiple factors such as ultrasound
contrast-enhanced ultrasound parameters and clinical related data in delayed graft function recovery
so as to establish a diagnostic model for delayed graft function recovery
and further provide an important basis for clinical diagnosis.Methods Retrospective analysis of 212 patients undergoing allogeneic renal transplantation after urologic surgery at the First Foshan People’s Hospital
including 157 cases in the transplanted kidney normalgraftfunction(NGF) group and 55 cases in the delayedgraftfunction(DGF) group.Clinical data
ultrasonography and contrast-enhanced ultrasonography(CEUS) were collected and analyzed by univariate analysis in both groups.Logistic regression analysis was performed with (whether it was DGF) as the dependent variable and (some variables with P<0.05) as the independent variable
and statistically significant indicators were obtained through the analysis
so as to establish a diagnostic model
draw the ROC curve and make a diagnostic evaluation.Results The height
weight and blood urea nitrogen(BUN) in DGF group of transplanted kidney function were higher than those in NGF group(both P<0.05)
and the hemoglobin index in DGF group of transplanted kidney function was lower than that in NGF group(P=0.004).The CEUS in DGF group showed that arrival intensity(AI)
peak intensity(PI)
echo enhancement intensity(A)
and area under the curve(AUC) were lower than those in the NGF group (both P<0.05);There were statistically significant differences in the peak systolic velocity(PSV) of interlobar arteries
resistance index(RI) of interlobar arteries
PSV of segmental arteries
RI of segmental arteries
RI of renal portal arteries and RI of anastomotic arteries between the two groups(both P<0.05).The above indicators were included in Logistic regression
and the differences in BUN
RI of interlobar arteries and AUC were statistically significant(both P<0.005).The diagnostic model was Logistic(P)=-3.363+0.169×BUN+0.794×RI of interlobar arteries-0.001×AUC.The cutoff for diagnosis of the model was 0.332
and the sensitivity of predicting DGF was 78.2%.The specificity
Youden index
positive predictive value and negative predictive value were 89.8%
68.0%
72.9% and 92.1%
respectively.Conclusion The diagnostic model of AUC in CEUS parameters
RI of interlobar arteries in ultrasonography parameters combined with BUN index has high sensitivity and specificity for early prediction of DGF of transplanted kidney