Application value of virtual touch tissue imaging quantification technique in detecting acute liver failure and evaluating the effect of preventive medication

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Application value of virtual touch tissue imaging quantification technique in detecting acute liver failure and evaluating the effect of preventive medication

更新时间：2023-10-09

- Application value of virtual touch tissue imaging quantification technique in detecting acute liver failure and evaluating the effect of preventive medication
- Journal of Clinical Ultrasound in Medicine Vol. 22, Issue 10, (2020)
- 作者机构：
  
  山西医科大学第二医院超声科
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2020，
  
  Published Online：28 October 2020，
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Application value of virtual touch tissue imaging quantification technique in detecting acute liver failure and evaluating the effect of preventive medication. [J]. Journal of Clinical Ultrasound in Medicine 22(10).(2020)
DOI：

Application value of virtual touch tissue imaging quantification technique in detecting acute liver failure and evaluating the effect of preventive medication. [J]. Journal of Clinical Ultrasound in Medicine 22(10).(2020) DOI：

摘要

目的探讨声触诊组织成像定量（VTIQ）技术在评估大鼠急性肝衰竭及预防性用药效果中的应用价值。方法将24只雄性SD大鼠随机分为对照组，模型组和治疗组，每组8只。治疗组予以美常安（100mg·kg-1·d-1 ）稀释后灌胃治疗，对照组及模型组每天给予同等量温生理盐水灌胃，共8天；模型组及治疗组于实验第6、7天注射TAA（200mg·kg-1 ·d-1），共两次。分别在造模前后测量三组大鼠肝脏的剪切波速度（SWV，单位m/s），比较三组SWV值是否存在差异，以病理结果为金标准评估肝脏损伤的程度。结果造模前对照组、模型组及治疗组SWVmean（m/s）分别为2.43±0.57、2.61±0.42和2.71±0.49，差异无统计学意义（P＞0.05）。造模后对照组、模型组及治疗组SWVmean（m/s）分别为2.50±0.71、3.56±0.48和3.06±0.27；模型组SWV较对照组升高，差异有统计学意义（P＜0.05）；预测ALF的截断值为2.83m/s，ROC曲线下面积、敏感度和特异度分别为0.938、100%和75.00%；治疗组SWV低于模型组，差异有统计学意义（P＜0.05）。结论 VTIQ技术在预测急性肝衰竭及评估预防性用药效果的中具有潜在应用价值。

Abstract

Objective To investigate the clinical application value of virtual touch tissue imaging quantification (VTIQ) technique in detecting acute liver failure（ALF） and evaluating the effect of preventive medication in rats.Materials and Methods Twenty-four male SD rats were randomly divided into the control group

the model group

and the treatment group

with eight rats in each group. The treatment group was treated by gavage with Medilac-S(100mg·kg-1·d-1) after?dilution

while the control group and the model group were treated with the same volume of warm normal saline for eight days.On the 6th and 7th day of the experiment

the model group and the treatment group were intraperitoneally injected with TAA (200mg·kg-1·d-1). The shear wave velocity(SWV

m/s) in the liver were measured and compared among three groups of rats before and after the establishment of the model，using pathological result as the gold standard to evaluate the degree of liver injury. Results Before modeling

the SWVmean(m/s) of control group

model group and treatment group were 2.43±0.57

2.61±0.42 and 2.71±0.49

the difference had no statistical significance(P＞0.05).After modeling

the SWVmean(m/s) of control group

model group and treatment group were 2.50±0.71

3.56±0.48 and 3.06±0.27.The SWVmean in the model group was higher than that in the control group

the difference had statistical significance(P＜0.05).With cut-off value of 2.83m/s

the AUC

sensitivity and specificity were 0.938

100% and 75.00% in predicting ALF. The SWVmean in the treatment group was lower than that in the model group

the difference had statistical significance(P＜0.05).Conclusion The VTIQ technique has potential application value in predicting acute liver failure and evaluating the effect of preventive medication.

关键词

急性肝衰竭超声检查声触诊组织成像定量硫代乙酰胺美常安

Keywords

Acute liver failureUltrasonographyVirtual touch tissue imaging quantificationThioacetamideMedilac-S

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