Correlation study between contrast-enhanced ultrasound quantitative parameters and  microvascular densities in papillary thyroid carcinomas

您当前的位置：

首页 >

文章列表页 >

Correlation study between contrast-enhanced ultrasound quantitative parameters and microvascular densities in papillary thyroid carcinomas

更新时间：2023-10-09

- Correlation study between contrast-enhanced ultrasound quantitative parameters and microvascular densities in papillary thyroid carcinomas
- Journal of Clinical Ultrasound in Medicine Vol. 22, Issue 10, (2020)
- 作者机构：
  
  陆军军医大学第一附属医院超声科
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2020，
  
  Published Online：28 October 2020，
扫描看全文
Correlation study between contrast-enhanced ultrasound quantitative parameters and microvascular densities in papillary thyroid carcinomas. [J]. Journal of Clinical Ultrasound in Medicine 22(10).(2020)
DOI：

Correlation study between contrast-enhanced ultrasound quantitative parameters and microvascular densities in papillary thyroid carcinomas. [J]. Journal of Clinical Ultrasound in Medicine 22(10).(2020) DOI：

摘要

摘要目的通过研究甲状腺乳头状癌（PTC）超声造影（CEUS）定量参数与微血管密度（MVD）间的相关性，为PTC的微血管评价提供一种非侵入性的术前检测方法。方法回顾性分析于我院超声科行甲状腺CEUS检查的甲状腺结节患者61例（共61个结节），分析结节的CEUS增强模式时间-强度曲线（TIC）定量参数，并与手术病理结果对照。应用CD31免疫组化法对手术切除的甲状腺结节进行免疫组化染色，计数MVD，Pearson法分析CEUS定量参数与MVD间的相关性。结果 CEUS提示55个PTC结节呈不均匀低增强，其诊断PTC的准确率为90.1%。PTC的TIC峰值强度（PI）及曲线下面积（AUC）分别为（14.47±6.42）dB、（603.1±222.80）dB·s，低于周围正常甲状腺组织的（21.06±5.65）dB、（1025.43±260.37）dB·s，差异均有统计学意义（均P＜0.05）。CD31免疫组化染色计数PTC结节的平均MVD值为（64.99±17.51）条/高倍视野，低于周边正常甲状腺组织的（91.71±7.54）条/高倍视野，差异有统计学意义（P＜0.05）。相关性分析显示PI、AUC与MVD有显著正相关性（r=0.811、0.734，P＜0.001）。结论 CEUS定量分析技术有助于提高PTC的诊断准确性。本研究为术前CEUS有效评价PTC提供了有用的研究基础和实验依据。

Abstract

ABSTRACT Objective Our aim is to investigate the correlation between CEUS quantitative parameters and MVD in thyroid papillary carcinoma（PTC），and also to provide a non-invasive preoperative detection method about microvascular evaluation for PTC.Methods Retrospective analysis was performed on 61 patients with thyroid nodules (61 nodules in total) who underwent thyroid CEUS examination in the ultrasound department of our hospital， Quantitative parameters of CEUS enhanced mode time-intensity curve (TIC) of thyroid nodules were analyzed and compared with surgical pathological results. CD31 immunohistochemical staining was performed on the surgically resected thyroid nodules to count MVD. Pearson method was used to analyze the correlation between CEUS quantitative parameters and MVD.Results CEUS indicated that 55 PTC nodules showed heterogeneous and low enhancement pattern. The accuracy of CEUS in diagnosing PTC was 90.1%. The TIC、PI and AUC 55 PTCs were （14.47±6.42）dB and （603.1±222.80）dB?s，respectively，which were lower than （21.06±5.65）dB and （1025.43±260.37） dB?s in the surrounding normal thyroid tissues，and differences were statistically significant（P<0.05）.The mean MVD of CD31 immunohistochemical staining PTC was （64.99±17.51） twigs/HP，which was lower than （91.71±7.54） twigs/HP in surrounding normal thyroid tissue，and the differences were statistically significant（P<0.05）.A significantly positive correlation was observed between PI 、 AUC and MVD in PTC（r=0.811、0.734，P＜0.001）. Conclusion CEUS and quantitative analysis can improve the diagnostic accuracy of thyroid nodules.This study provides useful research basis and experimental basis for the effective evaluation of PTC for CEUS before preoperative.

关键词

超声造影造影剂峰值强度微血管密度甲状腺乳头状癌

Keywords

references

查看原文

Views

637

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Correlation between contrast-enhanced ultrasonography and Ki-67 expression in cervical metastatic lymph nodes of NSCLC

Contrast-enhanced ultrasound enhancement features of clear cell renal cell carcinoma using Sonazoid or SonoVue as ultrasound contrast agents and comparative study with contrast-enhanced CT

Comparison of contrast-enhanced ultrasound and quantitative ultrasound indicators to explore the consistency of renal blood perfusion in chronic renal disease

Application of Targeted Ultrasound Contrast Agent Sonazoid in the Evaluation of Chemotherapy Efficacy in Metastatic Liver Cancer

Contrast-enhanced ultrasonic diagnosis of Intramural gallbladder hematoma：a case report

Related Author

刘蓉

周畅

周军

许涛

韦力

张凯

黄浩

张少飞

Related Institution

湖北省宜昌市伍家岗区宜昌市中心人民医院

山西医科大学第二医院

山西医科大学医学影像学院

绵阳市中心医院

川北医学院附属医院放射科

⁰