Correlation analysis of ultrasound characteristics, BRAFV600E gene mutation and cervical lymph node metastasis in papillary thyroid carcinoma

您当前的位置：

首页 >

文章列表页 >

Correlation analysis of ultrasound characteristics, BRAFV600E gene mutation and cervical lymph node metastasis in papillary thyroid carcinoma

更新时间：2023-10-11

- Correlation analysis of ultrasound characteristics, BRAFV600E gene mutation and cervical lymph node metastasis in papillary thyroid carcinoma
- Journal of Clinical Ultrasound in Medicine Vol. 25, Issue 4, (2023)
- 作者机构：
  
  陆军军医大学大坪医院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2023，
  
  Published Online：28 April 2023，
扫描看全文
Correlation analysis of ultrasound characteristics, BRAFV600E gene mutation and cervical lymph node metastasis in papillary thyroid carcinoma. [J]. Journal of Clinical Ultrasound in Medicine 25(4).(2023)
DOI：

Correlation analysis of ultrasound characteristics, BRAFV600E gene mutation and cervical lymph node metastasis in papillary thyroid carcinoma. [J]. Journal of Clinical Ultrasound in Medicine 25(4).(2023) DOI：

摘要

目的分析甲状腺乳头状癌（PTC）二维超声图像特征及BRAF V600E突变与颈部淋巴结转移的关系。方法选取于我院行甲状腺癌根治术患者316例，根据甲状腺癌术后病理分期（pTNM），将无颈部淋巴结转移（pN0）者归为（未转移组），有颈部淋巴结转移（pN1）者归为转移组，比较两组二维超声图像特征、临床资料、BRAF V600E突变的差异。采用多因素Logistic回归分析PTC超声图像特征、BRAF V600E突变与颈部淋巴结转移的关系。结果 316例PTC患者中，转移组156例（49.4%），98例（62.8%）发生BRAF V600E突变；未转移组160例（50.6%），121例（75.6%）发生BRAF V600E突变。转移组与未转移组在年龄、病灶数目、大小、沙粒钙化、纵横比、肿瘤边缘、病灶与被膜关系、累及腺叶比较，差异均有统计学意义（均P＜0.05）。多因素Logistic回归分析显示，患者年龄、肿瘤大小、沙粒钙化、纵横比、病灶与被膜关系、累及腺叶是发生颈部淋巴结转移的危险因素（均P＜0.05）。结论 PTC颈部淋巴结转移与患者年龄、肿瘤大小、沙粒钙化、纵横比、病灶与被膜、累及腺叶关系有关，与性别、病灶数目、肿瘤边缘、BRAF V600E突变无关。

Abstract

ABSTRACT Objective To analyze the characteristics of two-dimensional ultrasound images of papillary thyroid carcinoma (PTC) and the relationship between BRAFV600E mutation and cervical lymph node metastasis. Methods 316 patients with thyroid cancer underwent radical surgery in our hospital were selected. According to the pathological stage (pTNM) of thyroid cancer after surgery

those without cervical lymph node metastasis (pN0) were classified as (non metastasis group)

and those with cervical lymph node metastasis (pN1) were classified as (metastasis group). The differences of two-dimensional ultrasound image characteristics

clinical data and BRAFV600E mutation between the two groups were compared. Multi-factor logistic regression analysis was used to analyze the characteristics of PTC ultrasound image and the relationship between BRAFV600E mutation and cervical lymph node metastasis. ResuLts Among 316 PTC patients

156 (49.4%) in the metastatic group

98 (62.8%) had BRAFV600E mutation; 160 (50.6%) in the non-metastatic group

121 (75.6%) had BRAFV600E mutation. There were statistically significant differences between the metastatic group and the non-metastatic group in terms of age

number and size of lesions

sand calcification

aspect ratio

tumor margin

the relationship between lesions and membrane

and involvement of glandular lobes (all P<0.05). Multivariate logistic regression analysis showed that patients' age

tumor size

sand calcification

aspect ratio

the relationship between lesion and membrane

and the involvement of glandular lobe were risk factors for pN1（all P< 0.05）. Conclusion The cervical lymph node metastasis of PTC is related to the patient's age

tumor size

sand calcification

aspect ratio

the relationship between the lesion and membrane

and the glandular lobe involved

but not to gender

number of lesions

tumor margin

and BRAF V600E mutation.

关键词

超声检查甲状腺乳头状癌声像图特征颈部淋巴结转移基因突变

Keywords

references

查看原文

Views

131

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Application value of Angio Planewave Ultrasensitive imaging and shear wave elastography in progress of chronic kidney disease

Prediction Model of Cervical Lymph Node Metastasis of Thyroid Micropapillary Carcinoma Based on Multimodal Ultrasound and Clinical Application

Contrast-enhanced ultrasound enhancement features of clear cell renal cell carcinoma using Sonazoid or SonoVue as ultrasound contrast agents and comparative study with contrast-enhanced CT

To Study The Related Factors Of Postpartum Diastasis of The Rectus Abdominis Based on High Frequency Ultrasound Combined With Shear Wave Elastography WANG Liang*,HUANG Jun2,WANG Xiaona2

Study on the application value of shear wave elastography in the diagnosis and curative effect evaluation of hypoxic-ischemic encephalopathy

Related Author

谢昭鹏

黄珊珊

牟霜

刘承玄

刘可

林奉森

梁华

黄浩

Related Institution

Chongqing Traditional Chinese Medicine Hospital

宁德师范学院附属宁德市医院内分泌科

山西医科大学第二医院

山西医科大学医学影像学院

广州市红十字会医院

⁰