Objective: To explore the value of multi-slice spiral CT (MSCT) combined with serum CA125 in the differential diagnosis of evaginated uterine fibroids and ovarian sex cord stromal tumors. Methods: A retrospective analysis of 63 cases of pathologically confirmed evaginated uterine fibroids (group A) and 51 cases of ovarian sex cord stromal tumors (group B) was performed. CT images were used to observe the blood supply arteries

relationships of ovarian veins and tumors of the two groups

tumor enhancement characteristics

presence or absence of ascites; meanwhile CT diagnosis was made combined with serum CA125 results

using pathological results as the gold standard to detect the diagnostic accuracy of the two methods. Results: In group A

the tumor was supplied by the uterine artery and uterine branch with or without ovarian artery. Normal ovarian tissue can be seen through the ovarian vein in most cases. Tumor enhancement is obvious

with "whirlpool sign". Serum CA125 is mostly normal

and it is not easy to be combined with ascites. In group B: The tumor was mainly supplied by the ovarian artery with or without uterine artery and ovarian branch. Ovarian vascular sign (OVPS) can be seen

and tracking the ovarian vein can’t show intact ovarian tissue. After enhancement

the tumor had no or mild delayed enhancement

and the serum CA125 increased

combined with ascites. The diagnostic accuracy rates of CT in group A and B were 90.48% (57/63) and 80.39% (41/51)

respectively

and combined with serum CA125 for tumors the figures were 93.65% (59/63) and 86.27% (44/51)

respectively. Conclusion: According to the CT characteristics of the tumor and the results of serum CA125

it has a higher differential diagnostic efficacy for female pelvic evaginated uterine fibroids and ovarian sex cord stromal tumors.