Objective: To analyze the epidemic trends and risk factors of ovarian cancer in Chinese women from 1990 to 2019

and to provide a more scientific basis for the prevention of ovarian cancer in China. Methods: The estimated numbers and age-standardized rates of incidence

death and disability-adjusted life years of ovarian cancer in China and other areas were obtained from the Global Disease Burden 2019 database

and the changes of epidemic burden and risk factors of ovarian cancer in China were compared and evaluated. The incident numbers and death numbers of ovarian cancer in China from 2020 to 2040 were predicted by the GLOBOCAN database. Results: Mainland China and Taiwan province in China had increased the incidence of ovarian cancer from 2.56/100 000 and 4.72/100 000 to 4.54/100 000 and 8.68/100 000 during 1990 to 2019

and the age standardized mortality increased from 1.76/100 000 and 2.63/100 000 to 2.77/100 000 and 3.84/100 000

which increased by more than half of the global

including Japanese and Singapore. Among them

women aged 50-54 had the highest incidence and the peak was 70-74 years old. The three major risk factors for ovarian cancer death in 2019 were high fasting blood glucose

high body mass index and occupational asbestos exposure. In the past 30 years

the age-standardized disability-adjusted life year rates (DALY) of ovarian cancer in China increased with rising socio-demographic index (SDI). In addition

according to the prediction of GLOBOCAN database

the disease burden of ovarian cancer in China would continue to increase. By 2040

the incident cases of patients would be expected to increase by 17.9% and the number of deaths would increase by 33.0% compared with 2020. Conclusion: The disease burden of ovarian cancer among women in China is still heavy and rising. It is necessary to take corresponding effective preventive measures for different age groups and risk groups and strengthen the monitoring of high-risk groups

so as to further reduce the disease burden.