Current situation of tuberculosis and research progress on its genetic susceptibility

Chen Xinyu

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Current situation of tuberculosis and research progress on its genetic susceptibility

更新时间：2023-04-16

- Current situation of tuberculosis and research progress on its genetic susceptibility
- Journal of Chongqing Medical University Vol. 47, Issue 12, Pages: 1441-1446(2022)
- 作者机构：
  
  遵义医科大学公共卫生学院,遵义,563000
- 作者简介：
- 基金信息：
- DOI：
  CLC： R52
- Published：2022，
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Chen Xinyu. Current situation of tuberculosis and research progress on its genetic susceptibility. [J]. Journal of Chongqing Medical University 47(12):1441-1446(2022)
DOI：

Chen Xinyu. Current situation of tuberculosis and research progress on its genetic susceptibility. [J]. Journal of Chongqing Medical University 47(12):1441-1446(2022) DOI：

摘要

结核病（tuberculosis，TB）是全球主要传染病死因之一，其传播广泛，并可侵犯全身各器官，对人类健康造成了巨大的威胁。TB发生发展受多因素影响，除传统的环境因素外，遗传多态性逐渐被人们重视，IFNG、P2X7、VDR等基因多态性已被发现与结核病易感性显著相关，相关研究势必为结核病预防和治疗带来新的思路。本文系统总结了结核病遗传易感性相关基因，为今后结核病预防提供参考。

Abstract

Tuberculosis (TB) is one of the main causes of infectious diseases-related death in the whole world

which spreads worldwide and can invade widely all organs of the body

which poses a great threat to human health. Its occurrence and development are affected by many factors. Besides traditional environmental factors

genetic polymorphism has been paid more and more attention. Studies with interferon-γ (IFNG)

P2X7

vitamin D receptor (VDR) and other gene polymorphisms have been found to be significantly associated with the susceptibility of tuberculosis

and related research is bound to bring new ideas for tuberculosis prevention and treatment. In this paper

we systematically summarizes the genes related to the genetic susceptibility of tuberculosis

providing reference for tuberculosis prevention in the future.

关键词

结核病流行病学遗传多态性

Keywords

tuberculosisepidemiologygenetic polymorphism

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Related Author

Zhang Lina

Ni Wenjing

Zhang Mengjie

Mi Weinuo

Sun Yu

Li Xingjia

Chen Guofang

Liu Chao

Related Institution

Department of Endocrinology，Suqian Hospital of Xuzhou Medical University

Department of Infectious Diseases， Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine

Department of Endocrinology，Jiangsu Provincial Hospital of Integrated Traditional Chinese and Western Medicine/Affiliated Hospital of Integrated Traditional Chinese and Western Medicine，Nanjing University of Chinese Medicine

Department of Endocrinology and Metabolism，Affiliated Hospital of Integrated Traditional Chinese and Western Medicine，Nanjing University of Chinese Medicine

Department of Endocrinology,the First Affiliated Hospital of Shantou University Medical College

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