Early diagnosis value of CD64 index levels in peripheral blood on postoperative traumatic sepsis

LU Hai-bin; ZHOU Jian; WANG Yao-li; CHEN Xi

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Early diagnosis value of CD64 index levels in peripheral blood on postoperative traumatic sepsis

更新时间：2023-05-22

- Early diagnosis value of CD64 index levels in peripheral blood on postoperative traumatic sepsis
- null Issue 5, (2016)
- 作者机构：
  
  第三军医大学大坪医院野战外科研究所重症医学科,重庆,400042
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2016，
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LU Hai-bin, ZHOU Jian, WANG Yao-li, et al. Early diagnosis value of CD64 index levels in peripheral blood on postoperative traumatic sepsis. [J]. null (5).(2016)
DOI：

LU Hai-bin, ZHOU Jian, WANG Yao-li, et al. Early diagnosis value of CD64 index levels in peripheral blood on postoperative traumatic sepsis. [J]. null (5).(2016) DOI：

摘要

摘要]目的探讨外周血CD64指数在创伤手术后脓毒症患者中的表达及早期诊断价值。方法以420例创伤患者为研究对象，按临床表现分为脓毒症组（130例）和普通组（290例）。采用流式细胞术检测外周血CD64，同时检测C-反应蛋白（CRP）及白细胞计数（WBC）水平。评价上述指标对创伤手术后脓毒症患者的早期诊断价值。结果脓毒症组患者外周血CD64指数及CRP、WBC水平明显高于普通组患者（P<0.05）；经过相应治疗后，脓毒症组患者外周血CD64指数、CRP及WBC水平均较治疗前显著降低（P<0.05）。相关性分析显示，外周血CD64指数与CRP水平呈显著正相关（r=0.79，P<0.01），而外周血CD64指数与WBC水平无显著相关性（r=0.028，P>0.05）。ROC曲线分析显示，以外周血CD64指数7.21为早期诊断创伤手术后脓毒症临界值时，诊断创伤手术后脓毒症的敏感性和特异性分别为85.1%和87.8%，ROC曲线下面积（AUC）为0.887（95%CI 0.784~0.929），显著优于CRP指标。结论CD64在创伤手术后脓毒症患者中高表达，其可作为早期诊断创伤手术后脓毒症的有效指标，具有一定的临床运用价值。

Abstract

Abstract: ObjectiveTo investigate the expression and early diagnosis value of CD64 index levels in peripheral blood cells in patients with postoperative traumatic sepsis.MethodsA number of 420 trauma patients were enrolled in the study

and they were divided into the postoperative traumatic sepsis group(130 cases) and postoperative general trauma group(290 cases) according to the clinical manifestations.The CD64 levels in peripheral blood were measured by flow cytometry

and the levels of C-reactive protein(CRP) and white blood cell count(WBC) were detected. The diagnostic value of these indexes on postoperative traumatic sepsis were evaluated.ResultsThe CD64 index

CRP and WBC levels in postoperative traumatic sepsis group were significantly higher than postoperative general trauma group(P<0.05). After appropriate treatment

the CD64 index

CRP and WBC levels decreased significantly compared with the preoperative levels(P<0.05).The correlation analysis showed that the CD64 index in peripheral blood and CRP level were positively correlated(r=0.79，P<0.01).However

the CD64 index in peripheral blood and WBC level were of no significant correlation(r=0.028，P>0.05).The ROC curve analysis showed that when CD64 index(7.21) considered as the boundary for early diagnosis of postoperative traumatic sepsis

the sensitivity and specificity of diagnosis for postoperative traumatic sepsis were 85.1% and 87.8%

the area under the ROC curve(AUC) was 0.865(95%CI 0.784~0.929)

which was significantly better than CRP index.ConclusionThe expression of CD64 is higher in patients with postoperative traumatic sepsis

which can be used as an effective indicator for early diagnosis of postoperative traumatic sepsis

and it has an important clinical application value.

关键词

CD64指数创伤脓毒症诊断

Keywords

CD64 indextraumasepsisdiagnosis

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