Objective To investigate the effect of Blynch suture combined with uterine tamponade balloon compression on migration and invasion of vascular endothelial cell in patients of pernicious placenta previa. Methods Eighty patients with pernicious placenta previa were enrolled in our hospital from January 2015 to June 2018. The 48 patients in the control group underwent conventional hemorrhage management and uterine wound suture

while the 32 patients in the observation group were treated with Blynch suture combined with uterine tamponade balloon compression. The basic and abnormal conditions

serum AFP

HCG and SFIt1 levels

and neonatal status were compared between the two groups. Results Intraoperative bleeding and length of hospital stay were significantly lower in the observation group compared with the control group. The serum levels of AFP

HCG and SFIt1 were significantly lower than those in the control group (P<0.05). There was no significant difference in neonatal status between the two groups. The incidence of adverse events was slightly lower in the observation group compared with the control group (P>0.05). Conclusion For patients with pernicious placenta previa

Blynch suture combined with uterine tamponade balloon compression can reduce intraoperative hemorrhage the migration and invasion ability of vascular endothelial cells

which is beneficial to the recovery of patients.