Prognostic values of expression of Let-7 family in breast cancer

GENG miao; PAN Jing-kun; LUO Yun; TIAN Lei; WANG Jian-hua

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Prognostic values of expression of Let-7 family in breast cancer

更新时间：2023-05-22

- Prognostic values of expression of Let-7 family in breast cancer
- null Issue 1, (2019)
- 作者机构：
  
  解放军总医院第二医学中心老年医学研究所,北京,100853
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2019，
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GENG miao, PAN Jing-kun, LUO Yun, et al. Prognostic values of expression of Let-7 family in breast cancer. [J]. null (1).(2019)
DOI：

GENG miao, PAN Jing-kun, LUO Yun, et al. Prognostic values of expression of Let-7 family in breast cancer. [J]. null (1).(2019) DOI：

摘要

目的探讨Let-7家族各成员与乳腺癌患者预后相关性，寻找更有效的乳腺癌防治分子靶标。方法利用Kaplan-Meier plotter在线数据库分析Let-7家族各成员（Let-7a、7b、7c、7d、7e、7f、7g、7i、miR-98、miR-202）表达与乳腺癌患者总生存期（OS）及临床病理参数的相关性

并得出相应的危险比(HR)、95%置信区间(CI)和P值。结果 Let-7a、Let-7b、Let-7c、Let-7e、Let-7f、Let-7g、miR-98高表达或miR-202低表达的患者有较好的OS(P＜0.05)；病理特征分析显示，Let-7a、Let-7b、 Let-7f、 Let-7g、 miR-98、 miR-202的表达与疾病临床分期存在相关性(P<0.05)。Let-7a、 Let-7b、 Let-7c、 Let-7e、 Let-7f、 Let-7g、 miR-98和miR-202与淋巴结表达存在相关性(P<0.05)；三阴乳腺癌患者OS则与Let-7b、Let-7c、Let-7g、miR-202表达显著相关(P＜0.05)。结论 Let-7与乳腺癌患者OS显著相关，各成员在乳腺癌中的预后判断中具有不同的价值，其中Let-7b、Let-7g、miR-202在不同临床参数及三阴乳腺癌中都显示出与预后密切相关，更有望成为乳腺癌防治靶标。

Abstract

Objective To explore the expression of miRLet-7 family members in breast cancer and its correlation with overall survivals(OS)

and to find more effective molecular targets for breast cancer prevention and treatment. Methods Kaplan-Meier (KM) plotter online database was used to analyze the correlation among the expression of Let-7 family members (Let-7a

miR-98

miR-202) correlated with overall survival (OS) and the prognosis and clinical pathological parameters of breast cancer patients

and Hazard ratio(HR)

95% confidence interval (CI)

and P value were determined.Results The study showed that the high expression level of Let-7a

Let-7b

Let-7c

Let-7e

Let-7f

Let-7g

miR-98 and the low expression level of miR-202 was associated with better OS for breast cancer patients (P＜0.05).We further assessed the prognostic value of Let-7 in different subtypes and clinical stage. The expression of Let-7a

Let-7b

Let-7f

Let-7g

miR-98

miR-202 was related to clinical stage (P＜0.05). Let-7a

Let-7b

Let-7c

Let-7e

Let-7f

Let-7g

miR-98 and miR-202 was related to lymph node status(P＜0.05).In triplenegative breast cancers (TNBC)

with breast cancer subtype

the expression of Let-7b

Let-7c

Let-7g and miR-202 was significantly correlated to overall survival(P＜0.05). Conclusion The Let-7 is significantly correlated with OS in breast cancer patients.The results suggested that members of the Let-7 have different values in predicting the prognosis of breast cancer. Among them

Let-7b

Let-7g and miR-202 are closely related with clinical stage and TNBC

and might promote development of Let-7 as targeted inhibitors for the treatment of breast cancer.

关键词

乳腺癌Let-7预后靶向治疗miRNA分子靶标

Keywords

breast cancerLet-7prognosistarget therapymiRNAmolecular targets

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Related Institution

Department of Hepatobiliary Surgery，Huanggang Central Hospital Affiliated to Changjiang University

Department of Oncology，Huanggang Central Hospital Affiliated to Changjiang University

Department of Pathology，Huanggang Central Hospital Affiliated to Changjiang University

Department of Breast Surgery，The First Affiliated Hospital of Xi'an Jiaotong University

Department of Obstetrics and Gynecology，Jingzhou Central Hospital/Jingzhou Hospital Affiliated to Yangtze University

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