Influence of laparoscopic radical gastrectomy on clinical stress parameters and postoperative complications in patients with gastric cancer

LI Ke-ke; HUO Lei; XU Ji-zong; GONG Jiang-bo; SONG Wen-jun

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Influence of laparoscopic radical gastrectomy on clinical stress parameters and postoperative complications in patients with gastric cancer

更新时间：2023-05-22

- Influence of laparoscopic radical gastrectomy on clinical stress parameters and postoperative complications in patients with gastric cancer
- null Issue 1, (2019)
- 作者机构：
  
  宜昌市第二人民医院普外科,三峡大学腔镜诊疗研究所,湖北,宜昌,443000
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2019，
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LI Ke-ke, HUO Lei, XU Ji-zong, et al. Influence of laparoscopic radical gastrectomy on clinical stress parameters and postoperative complications in patients with gastric cancer. [J]. null (1).(2019)
DOI：

LI Ke-ke, HUO Lei, XU Ji-zong, et al. Influence of laparoscopic radical gastrectomy on clinical stress parameters and postoperative complications in patients with gastric cancer. [J]. null (1).(2019) DOI：

摘要

目的探讨腹腔镜手术对胃癌患者临床应激指标及术后并发症的影响。方法将2015年1月至2017年1月在我院普外科手术治疗的96例胃癌患者按照手术方式不同分为腹腔镜组和开腹组，各48例；对比2组患者手术时间、出血量、清扫淋巴结数目、术后住院时间、肛门排气时间、术后6个月并发症情况；应用酶联免疫吸附法（ELISA）检测并比较术前及术后1 d外周血白细胞（WBC）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）的水平。结果腹腔镜组患者的出血量、住院时间、术后肛门排气时间均优于开腹组，手术时间长于开腹组、清扫淋巴结数目少于开腹组，2组比较差异有极显著性统计学意义（P＜0.01）；术后1 d腹腔镜组患者的WBC、CRP、TNF-α、IL-6低于开腹组，差异有统计学意义（P＜0.05）；腹腔镜组术后6个月并发症发生率为22.8%，低于开腹组的54.7%，2组比较差异有统计学意义（P＜0.05）。结论与传统开腹手术相比，腹腔镜下胃癌根治术在减少住院时间及术中失血量的同时，还能降低应激反应、减少术后并发症发生率。

Abstract

Objective To investigate the effect of the laparotomy and laparoscopic surgery on the stress parameters and complication of patients with gastric cancer. Methods A total of 96 patients diagnosed as gastric cancer and treated by surgery in our hospital from January 2015 to January 2017 were divided into open operation group and laparoscopy group according to the operation method

48 cases in each group. Compared the operation time

bleeding volume

dissected lymph node number

postoperative hospitalization duration and anus exhausting time and complications in 6 months after surgery.The levels of WBC

CRP

TNF-α

IL-6 in serum before and after operation were detected by enzyme-linked immuno sorbent assay and compared. Results Compared with the open operation group

the bleeding volume

postoperative hospitalization duration and anus exhausting time of laparoscopy group were better with less dissected lymph node number and longer operation time

the differences were extremely significant(P<0.01);the WBC

CRP

TNF-α

IL-6 levels of laparoscopy group at 1 day after the operation were lower than those of open operation group(P<0.05).The incidence of complication of laparoscopy group was 22.8%

which was less than 54.7% of control group

the difference was significant（P＜0.05）.Conclusion Compared with the traditional open operation

laparoscopic radical gastrectomy can shorten the hospital stays and reduce the intraoperative blood loss

the stress response and complication rate after operation.

关键词

开腹手术腹腔镜胃癌根治术应激炎症因子并发症

Keywords

open operationlaparoscopegastrectomystressinflammation factorscomplication

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